ReviewMetabolites2021
Salt Sensation and Regulation.
Review in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Molecular and neural mechanisms of sodium sensation.Genes & genomics · 2026Review
- Pleiotropic Cholesterol Signaling inMetabolites · 2026Review
- Electrochemical Sensors as a Tool for Taste Perception in Pharmaceutical Products: Advances and Perspectives.Biosensors · 2026Review
- Evolutionary analysis ofFrontiers in plant science · 2026Article
- Targeted cravings: Unraveling the drivers of nutrient-specific appetite.Current opinion in neurobiology · 2025Review
- Calcium levels in ASER neurons determine behavioral valence by engaging distinct neuronal circuits in C. elegans.Nature communications · 2025Article
- Progress in Multisensory Synergistic Salt Reduction.Foods (Basel, Switzerland) · 2024Review
- Low sodium availability in hydroponically manipulated host plants promotes cannibalism in a lepidopteran herbivore.Scientific reports · 2023Article
- Molecular Basis of Hexanoic Acid Taste inMolecules and cells · 2023Article
- Salty and Savoury Snacks Compliance with 2016 and 2019 Sodium Content Targets-Durban Market, South Africa.International journal of environmental research and public health · 2022Article
- Mechanisms of Carboxylic Acid Attraction inMolecules and cells · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Taste sensation and regulation are highly conserved in insects and mammals. Research conducted over recent decades has yielded major advances in our understanding of the molecular mechanisms underlying the taste sensors for a variety of taste sensations and the processes underlying regulation of ingestion depending on our internal state. Salt (NaCl) is an essential ingested nutrient. The regulation of internal sodium concentrations for physiological processes, including neuronal activity, fluid volume, acid-base balance, and muscle contraction, are extremely important issues in animal health. Both mammals and flies detect low and high NaCl concentrations as attractive and aversive tastants, respectively. These attractive or aversive behaviors can be modulated by the internal nutrient state. However, the differential encoding of the tastes underlying low and high salt concentrations in the brain remain unclear. In this review, we discuss the current view of taste sensation and modulation in the brain with an emphasis on recent advances in this field. This work presents new questions that include but are not limited to, "How do the fly's neuronal circuits process this complex salt code?" and "Why do high concentrations of salt induce a negative valence only when the need for salt is low?" A better understanding of regulation of salt homeostasis could improve our understanding of why our brains enjoy salty food so much.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.