Evidence map›Paper›PMID 33803295›Full record

ReviewMedicina (Kaunas, Lithuania)2021

Does COVID-19 Vaccination Warrant the Classical Principle "

Michael Doulberis, Apostolis Papaefthymiou, Georgios Kotronis, Dimitra Gialamprinou, Elpidoforos S Soteriades, Anthony Kyriakopoulos, Eleftherios Chatzimichael, Kyriaki Kafafyllidou, Christos Liatsos, Ioannis Chatzistefanou and 11 more

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022
    Article
  5. Article
  6. Medicina (Kaunas, Lithuania) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Michael DoulberisSecond Medical Clinic, School of Medicine, Aristotle University of Thessaloniki, Ippokration Hospital, 54652 Thessaloniki, Greece.ORCID 0000-0002-0396-5081
Apostolis PapaefthymiouSecond Medical Clinic, School of Medicine, Aristotle University of Thessaloniki, Ippokration Hospital, 54652 Thessaloniki, Greece.ORCID 0000-0002-3563-4973
Georgios KotronisDepartment of Internal Medicine, General Hospital Aghios Pavlos of Thessaloniki, 55134 Thessaloniki, Greece.
Dimitra GialamprinouSecond Neonatal Department and NICU, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56403 Thessaloniki, Greece.
Elpidoforos S SoteriadesHealthcare Management Program, School of Economics and Management, Open University of Cyprus, Nicosia 2252, Cyprus.
Anthony KyriakopoulosNasco AD Biotechnology Laboratory, Department of Research and Development, 18536 Piraeus, Greece.ORCID 0000-0002-0749-0060
Eleftherios ChatzimichaelCenter for Integrative Psychiatry, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital of Zurich, University of Zurich, 8032 Zurich, Switzerland.
Kyriaki KafafyllidouDepartment of Pediatrics, University Children's Hospital of Zurich, 8032 Zurich, Switzerland.
Christos LiatsosDepartment of Gastroenterology, 401 Army General Hospital of Athens, 11525 Athens, Greece.ORCID 0000-0001-8025-0808
Ioannis ChatzistefanouDepartment of Maxillofacial Surgery, 424 General Military Hospital, Ring Road Efkarpia, 56429 Thessaloniki, Greece.ORCID 0000-0001-7463-6106
Paul AnagnostisORL and Psychiatry Private Practice, 8032 Zurich, Switzerland.
Vitalii SemeninNeurology and Psychiatry Private Practice, 2502 Biel, Switzerland.
Smaragda NtonaAlexandrovska University Hospital, Medical University Sofia, 1431 Sofia, Bulgaria.
Ioanna GkoliaPsychiatric Hospital of Thessaloniki, Stavroupolis, 56429 Thessaloniki, Greece.
Dimitrios David PapazoglouDepartment of General, Visceral and Thoracic Surgery, Bürgerspital Solothurn, 4500 Solothurn, Switzerland.
Nikolaos TsinonisGeneral Practitioner, Private Practice, 8032 Zurich, Switzerland.
Spyros PapamichosSecond Medical Clinic, School of Medicine, Aristotle University of Thessaloniki, Ippokration Hospital, 54652 Thessaloniki, Greece.ORCID 0000-0001-7119-0647
Hristos KirbasDepartment of Nuclear Medicine, "Thegeneio" Cancer Hospital, 54007 Thessaloniki, Greece.
Petros ZikosDepartment of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
Dionisios NiafasFOB AKTION, 30002 Aktio, Greece.
Jannis KountourasSecond Medical Clinic, School of Medicine, Aristotle University of Thessaloniki, Ippokration Hospital, 54652 Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic warrants an imperative necessity for effective and safe vaccination, to restrain Coronavirus disease 2019 (COVID-19) including transmissibility, morbidity, and mortality. In this regard, intensive medical and biological research leading to the development of an arsenal of vaccines, albeit incomplete preconditioned evaluation, due to emergency. The subsequent scientific gap raises some concerns in the medical community and the general public. More specifically, the accelerated vaccine development downgraded the value of necessary pre-clinical studies to elicit medium- and long-term beneficial or harmful consequences. Previous experience and pathophysiological background of coronaviruses' infections and vaccine technologies, combined with the global vaccines' application, underlined the obligation of a cautious and qualitative approach, to illuminate potential vaccination-related adverse events. Moreover, the high SARS-CoV-2 mutation potential and the already aggregated genetical alterations provoke a rational vagueness and uncertainty concerning vaccines' efficacy against dominant strains and the respective clinical immunity. This review critically summarizes existing evidence and queries regarding SARS-CoV-2 vaccines, to motivate scientists' and clinicians' interest for an optimal, individualized, and holistic management of this unprecedented pandemic.

Indexed as

2019-nCoV Vaccine mRNA-1273Adjuvants, ImmunologicAutoimmune DiseasesBNT162 VaccineChAdOx1 nCoV-19COVID-19COVID-19 VaccinesDrug ApprovalDrug Evaluation, PreclinicalHippocratic OathHumansLong Term Adverse EffectsModels, AnimalmRNA VaccinesRisk AssessmentSARS-CoV-22019-nCoV Vaccine mRNA-1273Adjuvants, ImmunologicBNT162 VaccineChAdOx1 nCoV-19COVID-19 VaccinesmRNA VaccinesVaccines, InactivatedVaccines, SyntheticCOVID-19Hippocratesofelein i mi vlaptinPrimum non nocereSARS-COV-2vaccinationvaccine

Identifiers

PMID33803295
PMCPMC7999356

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.