Evidence map›Paper›PMID 33803597›Full record

ArticleAnimals : an open access journal from MDPI2021

Processing Matters in Nutrient-Matched Laboratory Diets for Mice-Microbiome.

Jasmin Wenderlein, Linda F Böswald, Sebastian Ulrich, Ellen Kienzle, Klaus Neuhaus, Ilias Lagkouvardos, Christian Zenner, Reinhard K Straubinger

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Article
  3. Study ofInternational journal of inflammation · 2025
    Article
  4. Article
  5. Article
  6. Powder diet exacerbates oropharyngeal candidiasis in a mouse model.Applied and environmental microbiology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jasmin WenderleinChair of Bacteriology and Mycology, Institute for Infectious Diseases and Zoonosis, Department of Veterinary Sciences, Faculty of Veterinary Medicine, LMU Munich, Veterinärstr. 13, 80539 Munich, Germany.
Linda F BöswaldChair of Animal Nutrition and Dietetics, Department of Veterinary Sciences, Faculty of Veterinary Medicine, LMU Munich, Schönleutenerstr. 8, 85764 Oberschleißheim, Germany.ORCID 0000-0002-5363-335X
Sebastian UlrichChair of Bacteriology and Mycology, Institute for Infectious Diseases and Zoonosis, Department of Veterinary Sciences, Faculty of Veterinary Medicine, LMU Munich, Veterinärstr. 13, 80539 Munich, Germany.ORCID 0000-0002-4511-9537
Ellen KienzleChair of Animal Nutrition and Dietetics, Department of Veterinary Sciences, Faculty of Veterinary Medicine, LMU Munich, Schönleutenerstr. 8, 85764 Oberschleißheim, Germany.
Klaus NeuhausCore Facility Microbiome, ZIEL-Institute for Food & Health, Technical University of Munich, Weihenstephaner Berg 3, 85354 Freising, Germany.ORCID 0000-0002-6020-2814
Ilias LagkouvardosCore Facility Microbiome, ZIEL-Institute for Food & Health, Technical University of Munich, Weihenstephaner Berg 3, 85354 Freising, Germany.ORCID 0000-0001-9337-4033
Christian ZennerVeterinary Immunology Study Group, Department for Veterinary Sciences, Faculty of Veterinary Medicine, LMU Munich, Lena-Christ-Str. 48, 82152 Planegg-Martinsried, Germany.
Reinhard K StraubingerChair of Bacteriology and Mycology, Institute for Infectious Diseases and Zoonosis, Department of Veterinary Sciences, Faculty of Veterinary Medicine, LMU Munich, Veterinärstr. 13, 80539 Munich, Germany.ORCID 0000-0001-8382-7182

Funding

H. Wilhelm Schaumann Stiftung not provided
6 · The paper itself

Abstract

The composition of the microbiome is subject to the host's diet. In commercial laboratory mouse diets, different physical forms of the same diets are available, containing-according to their labels-identical ingredients and nutrient compositions. However, variations in nutrient composition and starch gelatinization due to production processes and their impact on digestibility have been described. In this study, a total of 48 C57BL/J6 mice were assigned to two equal groups and were fed diets (produced with different processes-extruded vs. pelleted) for eight weeks in two biological replicates. At the end of the experiment, samples were collected from five different gastrointestinal regions, including the stomach, small intestine, cecum, large intestine, and an extracorporeal region (feces), and the microbiome was analyzed with 16S rRNA gene amplicon sequencing. The replicates in both experiments differed significantly in their relative abundances of Muribaculaceae species. Furthermore, the gastrointestinal content of pellet-fed mice contained larger numbers of

Indexed as

dietfeed processingintestinal microbiomelaboratory mousestarch gelatinization

Identifiers

PMID33803597
PMCPMC8002992

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.