ReviewJournal of clinical medicine2021
Screening for Gestational Diabetes Mellitus in Early Pregnancy: What Is the Evidence?
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- National and regional prevalence of gestational diabetes mellitus in India: a systematic review and Meta-analysis.BMC public health · 2024Pooled it
- Does fasting plasma glucose values 5.1-5.6 mmol/l in the first trimester of gestation a matter?Frontiers in endocrinology · 2023Trial
- Patient Engagement Strategies for Women with Gestational Diabetes Mellitus in Low-Resource Community Health Settings: A Narrative Review and Clinical Principles.Healthcare (Basel, Switzerland) · 2026Review
- Metabolic challenges in rheumatoid arthritis: a translational overview from pathogenesis to patient care.Acta diabetologica · 2026Review
- Machine Learning-Based Early Prediction of Gestational Diabetes Using First-Trimester Laboratory Parameters.Cureus · 2026Article
- Comprehensive Review of Gestational Diabetes: Pathophysiology, Pharmacological Management and the Role of Pharmaceutical Care.Current drug safety · 2026Review
- Early pregnancy meal tolerance test responses and their association with later insulin sensitivity in overweight and obese women: an exploratory analysis.Frontiers in endocrinology · 2026Observational
- Levels of Cu, Zn, and Se in Maternal and Cord Blood in Normal and Pathological Pregnancies: A Narrative Review.International journal of molecular sciences · 2025Review
- The utility of early gestational OGTT and biomarkers for the development of gestational diabetes mellitus: an international prospective multicentre cohort study.Diabetologia · 2025Observational
- Nursing Care in Obstetrics and Breastfeeding Practices in Gestational Diabetic Mothers in China: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2025Review
- Life-course management of gestational diabetes mellitus: A narrative review.World journal of clinical cases · 2025Article
- Navigating Diabetes in Pregnancy: Critical Approaches to Mitigate Risks and Improve Outcomes for Mother and Child.Metabolites · 2025Review
- Beyond one size fits all: Probing patient choices in gestational diabetes management, from screening to postpartum.Chronic diseases and translational medicine · 2025Review
- Review
- Can aspartate aminotransferase and platelet distribution width-to-platelet ratio in the first trimester predict fetal macrosomia?: a retrospective case-control study.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Non-Pharmacological Management of Gestational Diabetes Mellitus with a High Fasting Glycemic Parameter: A Hospital-Based Study in Vietnam.Journal of clinical medicine · 2024Article
- Cost-effectiveness of diagnosis and treatment of early gestational diabetes mellitus: economic evaluation of the TOBOGM study, an international multicenter randomized controlled trial.EClinicalMedicine · 2024Article
- First-trimester HbADiabetology & metabolic syndrome · 2024Article
- New perspective on first-trimester serum uric acid level in predicting the risk of gestational diabetes mellitus.Scientific reports · 2024Article
- Thyroid dysfunction during gestation and gestational diabetes mellitus: a complex relationship.Journal of endocrinological investigation · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of gestational diabetes mellitus (GDM) is increasing worldwide. This has a significant effect on the health of the mother and offspring. There is no doubt that screening for GDM between 24 and 28 weeks is important to reduce the risk of adverse pregnancy outcomes. However, there is no consensus about diagnosis and treatment of GDM in early pregnancy. In this narrative review on the current evidence on screening for GDM in early pregnancy, we included 37 cohort studies and eight randomized controlled trials (RCTs). Observational studies have shown that a high proportion (15-70%) of women with GDM can be detected early in pregnancy depending on the setting, criteria used and screening strategy. Data from observational studies on the potential benefit of screening and treatment of GDM in early pregnancy show conflicting results. In addition, there is substantial heterogeneity in age and BMI across the different study populations. Smaller RCTs could not show benefit but several large RCTs are ongoing. RCTs are also necessary to determine the appropriate cut-off for HbA1c in pregnancy as there is limited evidence showing that an HbA1c ≥6.5% has a low sensitivity to detect overt diabetes in early pregnancy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.