ReviewInsects2021
From Global to Local-New Insights into Features of Pyrethroid Detoxification in Vector Mosquitoes.
Review in Insects, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Resistance to pyrethroids in Aedes aegypti: Insights into transcriptomic response to different insecticide concentrations.PLoS neglected tropical diseases · 2026Article
- Metabolomic Changes Underpinning Permethrin Resistance in theACS measurement science au · 2026Article
- Synergistic action of different molecular mechanisms causes striking levels of insecticide resistance in the malaria vectorProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- Cytochrome P450 Monooxygenase Mediated Pyrethroid Resistance in the Urban Dengue Vector, Aedes aegypti (Diptera: Culicidae) from Northern Part of West Bengal, India.Acta parasitologica · 2026Article
- Biochemical, molecular, and in silico insights into the effects of cyphenothrin on Culex quinquefasciatus mosquitoes.Parasites & vectors · 2026Article
- Potent and selective indole-based inhibitors targeting disease-transmitting mosquitoes.RSC medicinal chemistry · 2026Article
- Metabolomic changes underpinning permethrin resistance in thebioRxiv : the preprint server for biology · 2026Article
- Expression of cytochrome P450 monooxygenase genes in pyrethroid-resistant Aedes albopictus.Scientific reports · 2025Article
- Pyrethroid resistance in Aedes aegypti: genetic mechanisms worldwide, and recommendations for effective vector control.Parasites & vectors · 2025Review
- Overexpression of cytochrome P450 and esterase genes in pyrethroid-resistant wild Culex quinquefasciatus populations from sub-Himalayan West Bengal, India.Parasitology research · 2025Article
- Eco-friendly bioactives from Nyctanthes arbor-tristis (L.) for targeted control of Aedes aegypti and Culex quinquefasciatus with reduced impact on Toxorhynchites splendens.Scientific reports · 2025Article
- Strong resistance to β-cyfluthrin in a strain of the beetle Alphitobius diaperinus: a de novo transcriptome analysis.Insect science · 2025Article
- Article
- Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from "window" entry.Journal of medical entomology · 2025Article
- Article
- Article
- ROY Crystallization on Poly(ethylene) Fibers, a Model for Bed Net Crystallography.Chemistry of materials : a publication of the American Chemical Society · 2024Article
- Article
- A Culex quinquefasciatus strain resistant to the binary toxin from Lysinibacillus sphaericus displays altered enzyme activities and energy reserves.Parasites & vectors · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The threat of mosquito-borne diseases continues to be a problem for public health in subtropical and tropical regions of the world; in response, there has been increased use of adulticidal insecticides, such as pyrethroids, in human habitation areas over the last thirty years. As a result, the prevalence of pyrethroid-resistant genetic markers in natural mosquito populations has increased at an alarming rate. This review details recent advances in the understanding of specific mechanisms associated with pyrethroid resistance, with emphasis on features of insecticide detoxification and the interdependence of multiple cellular pathways. Together, these advances add important context to the understanding of the processes that are selected in resistant mosquitoes. Specifically, before pyrethroids bind to their targets on motoneurons, they must first permeate the outer cuticle and diffuse to inner tissues. Resistant mosquitoes have evolved detoxification mechanisms that rely on cytochrome P450s (CYP), esterases, carboxyesterases, and other oxidation/reduction (redox) components to effectively detoxify pyrethroids to nontoxic breakdown products that are then excreted. Enhanced resistance mechanisms have evolved to include alteration of gene copy number, transcriptional and post-transcriptional regulation of gene expression, as well as changes to cellular signaling mechanisms. Here, we outline the variety of ways in which detoxification has been selected in various mosquito populations, as well as key gene categories involved. Pathways associated with potential new genes of interest are proposed. Consideration of multiple cellular pathways could provide opportunities for development of new insecticides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.