Evidence map›Paper›PMID 33805190›Full record

ReviewGenes2021

Insect Behavioral Change and the Potential Contributions of Neuroinflammation-A Call for Future Research.

Colleen A Mangold, David P Hughes

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Entomopathogenic fungi: insights into recent understanding.World journal of microbiology & biotechnology · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Unraveling the Role of Antimicrobial Peptides in Insects.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
  9. Expression of trematode-induced zombie-ant behavior is strongly associated with temperature.Behavioral ecology : official journal of the International Society for Behavioral Ecology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Colleen A MangoldDepartment of Entomology, College of Agricultural Sciences, Pennsylvania State University, University Park, State College, PA 16802, USA.ORCID 0000-0001-7205-4540
David P HughesDepartment of Entomology, College of Agricultural Sciences, Pennsylvania State University, University Park, State College, PA 16802, USA.
Pennsylvania State University · US

Funding

From Cells to Societies: Mechanisms by Which Microbial Parasites Control Host PhenotypesR01GM116927 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CHEN, DANNY ZIYI, HANKS, EPHRAIM · 2016 to 2020
$1.7M
NIGMS NIH HHS R01 GM116927
6 · The paper itself

Abstract

Many organisms are able to elicit behavioral change in other organisms. Examples include different microbes (e.g., viruses and fungi), parasites (e.g., hairworms and trematodes), and parasitoid wasps. In most cases, the mechanisms underlying host behavioral change remain relatively unclear. There is a growing body of literature linking alterations in immune signaling with neuron health, communication, and function; however, there is a paucity of data detailing the effects of altered neuroimmune signaling on insect neuron function and how glial cells may contribute toward neuron dysregulation. It is important to consider the potential impacts of altered neuroimmune communication on host behavior and reflect on its potential role as an important tool in the "neuro-engineer" toolkit. In this review, we examine what is known about the relationships between the insect immune and nervous systems. We highlight organisms that are able to influence insect behavior and discuss possible mechanisms of behavioral manipulation, including potentially dysregulated neuroimmune communication. We close by identifying opportunities for integrating research in insect innate immunity, glial cell physiology, and neurobiology in the investigation of behavioral manipulation.

Indexed as

Immunity, InnateAnimalsBehavior, AnimalHost-Parasite InteractionsNeurogliaNeuronsWaspsbehavioral manipulationgliainsect innate immunity

Identifiers

PMID33805190
PMCPMC8064348
OpenAlexW3136515992

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.