Evidence map›Paper›PMID 33806203›Full record

ArticleInternational journal of molecular sciences2021

Amyloid-Beta Induces Different Expression Pattern of Tissue Transglutaminase and Its Isoforms on Olfactory Ensheathing Cells: Modulatory Effect of Indicaxanthin.

Agata Campisi, Giuseppina Raciti, Giovanni Sposito, Rosaria Grasso, Maria A Chiacchio, Michela Spatuzza, Alessandro Attanzio, Ugo Chiacchio, Luisa Tesoriere, Mario Allegra and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Indicaxanthin fromAntioxidants (Basel, Switzerland) · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Agata CampisiDepartment of Drug Sciences and Health, University of Catania, 95125 Catania, Italy.ORCID 0000-0002-9808-4681
Giuseppina RacitiDepartment of Drug Sciences and Health, University of Catania, 95125 Catania, Italy.
Giovanni SpositoDepartment of Drug Sciences and Health, University of Catania, 95125 Catania, Italy.ORCID 0000-0002-2227-1528
Rosaria GrassoDepartment of Physics and Astronomy "Ettore Majorana", University of Catania, 95123 Catania, Italy.ORCID 0000-0003-4864-9880
Maria A ChiacchioDepartment of Drug Sciences and Health, University of Catania, 95125 Catania, Italy.
Michela SpatuzzaInstitute for Biomedical Research and Innovation (IRIB), National Research Council, 95126 Catania, Italy.
Alessandro AttanzioDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128 Palermo, Italy.ORCID 0000-0002-6622-028X
Ugo ChiacchioDepartment of Drug Sciences and Health, University of Catania, 95125 Catania, Italy.
Luisa TesoriereDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128 Palermo, Italy.ORCID 0000-0002-7980-7530
Mario AllegraDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128 Palermo, Italy.ORCID 0000-0002-5846-1868
Rosalia PellitteriInstitute for Biomedical Research and Innovation (IRIB), National Research Council, 95126 Catania, Italy.ORCID 0000-0002-1551-5467
University of Catania · ITUniversity of Palermo · ITInstitute for Biomedical Research and Innovation · IT

Funding

Piano della ricerca 2016-2018, Dotazione Ordinaria, Linea di intervento 2 0003690
6 · The paper itself

Abstract

Herein, we assessed the effect of full native peptide of amyloid-beta (Aβ) (1-42) and its fragments (25-35 and 35-25) on tissue transglutaminase (TG2) and its isoforms (TG2-Long and TG2-Short) expression levels on olfactory ensheathing cells (OECs). Vimentin and glial fibrillary acid protein (GFAP) were also studied. The effect of the pre-treatment with indicaxanthin from Opuntia ficus-indica fruit on TG2 expression levels and its isoforms, cell viability, total reactive oxygen species (ROS), superoxide anion (O

Indexed as

Gene Expression Regulation, EnzymologicAlzheimer DiseaseAmyloid beta-PeptidesAnimalsApoptosisBetaxanthinsCell DifferentiationCyclin D1Glial Fibrillary Acidic ProteinGTP-Binding ProteinsHumansMiceNerve RegenerationNestinOlfactory BulbOpuntiaAmyloid beta-PeptidesBetaxanthinsCyclin D1Glial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mouseGTP-Binding ProteinsindicaxanthinNes protein, mouseNestinProtein Glutamine gamma Glutamyltransferase 2Protein IsoformsPyridinesReactive Oxygen SpeciesTransglutaminasesVimentinVim protein, mouseamyloid-betaIndicaxanthinolfactory ensheathing cellsoxidative stressself-renewaltissue transglutaminase

Identifiers

PMID33806203
PMCPMC8037686
OpenAlexW3134303689

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.