Evidence map›Paper›PMID 33806219›Full record

ArticleInternational journal of molecular sciences2021

Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?

Sylwia Grabska-Zielińska, Alina Sionkowska, Ewa Olewnik-Kruszkowska, Katarzyna Reczyńska, Elżbieta Pamuła

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sylwia Grabska-ZielińskaDepartment of Physical Chemistry and Physicochemistry of Polymers, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland.ORCID 0000-0003-3957-9542
Alina SionkowskaDepartment of Chemistry of Biomaterials and Cosmetics, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland.ORCID 0000-0002-1551-2725
Ewa Olewnik-KruszkowskaDepartment of Physical Chemistry and Physicochemistry of Polymers, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland.ORCID 0000-0002-8407-0078
Katarzyna ReczyńskaDepartment of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, 30-059 Kraków, Poland.
Elżbieta PamułaDepartment of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, 30-059 Kraków, Poland.ORCID 0000-0002-0464-6189
Nicolaus Copernicus University · PLAGH University of Krakow · PL

Funding

"Excellence Initiative - Research University" for the AGH University of Science and Technology (AGH-UST)"Excellence Initiative - Research University" for the Nicolaus Copernicus University in Toruń (4xI@NCU)Faculty of Materials Science and Ceramics, AGH-UST (Subsidy No. 16.16.160.557)Narodowe Centrum Nauki 2018/31/N/ST8/01391
6 · The paper itself

Abstract

The aim of this work was to compare physicochemical properties of three dimensional scaffolds based on silk fibroin, collagen and chitosan blends, cross-linked with dialdehyde starch (DAS) and dialdehyde chitosan (DAC). DAS was commercially available, while DAC was obtained by one-step synthesis. Structure and physicochemical properties of the materials were characterized using Fourier transfer infrared spectroscopy with attenuated total reflectance device (FTIR-ATR), swelling behavior and water content measurements, porosity and density observations, scanning electron microscopy imaging (SEM), mechanical properties evaluation and thermogravimetric analysis. Metabolic activity with AlamarBlue assay and live/dead fluorescence staining were performed to evaluate the cytocompatibility of the obtained materials with MG-63 osteoblast-like cells. The results showed that the properties of the scaffolds based on silk fibroin, collagen and chitosan can be modified by chemical cross-linking with DAS and DAC. It was found that DAS and DAC have different influence on the properties of biopolymeric scaffolds. Materials cross-linked with DAS were characterized by higher swelling ability (~4000% for DAS cross-linked materials; ~2500% for DAC cross-linked materials), they had lower density (Coll/CTS/30SF scaffold cross-linked with DAS: 21.8 ± 2.4 g/cm

Indexed as

AnimalsBiocompatible MaterialsBiopolymersBone and BonesCell AdhesionCell Line, TumorChitosanCollagenCross-Linking ReagentsFibroinsHumansMicroscopy, Electron, ScanningOsteoblastsPorosityRatsRegenerative MedicineBiocompatible MaterialsBiopolymersChitosanCollagenCross-Linking ReagentsFibroinscross-linkingdialdehyde chitosandialdehyde starchscaffolds

Identifiers

PMID33806219
PMCPMC8037002
OpenAlexW3142432168

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.