Evidence map›Paper›PMID 33807246›Full record

ArticleCells2021

Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles Elicit Better Preservation of the Intra-Renal Microvasculature Than Renal Revascularization in Pigs with Renovascular Disease.

Christopher M Ferguson, Rahele A Farahani, Xiang-Yang Zhu, Hui Tang, Kyra L Jordan, Ishran M Saadiq, Amir Lerman, Lilach O Lerman, Alfonso Eirin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Extracellular vesicles and their effect on vascular haemodynamics: a systematic review.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Christopher M FergusonDepartment of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55901, USA.
Rahele A FarahaniDepartment of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55901, USA.
Xiang-Yang ZhuDepartment of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55901, USA.
Hui TangDepartment of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55901, USA.
Kyra L JordanDepartment of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55901, USA.
Ishran M SaadiqDepartment of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55901, USA.
Amir LermanDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55901, USA.
Lilach O LermanDepartment of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55901, USA.ORCID 0000-0002-3271-3887
Alfonso EirinDepartment of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55901, USA.ORCID 0000-0002-3864-9644
Mayo Clinic · USMayo Clinic in Florida · US

Funding

Obesity-induced mesenchymal stem cell senescenceR01DK120292 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2019 to 2022
$2.6M
Quantitative magnetization transfer MRI for evaluation of renal fibrosisR01DK122734 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2020 to 2023
$2.2M
A potential role for mitoprotection in preserving the kidney in metabolic syndrome and renal artery stenosisK08DK106427 · NIDDK · MAYO CLINIC ROCHESTER · PI EIRIN, ALFONSO · 2015 to 2019
$819k
Mitochondrial injury interferes with endogenous renal repair in experimental renovascular diseaseR03DK122137 · NIDDK · MAYO CLINIC ROCHESTER · PI EIRIN, ALFONSO · 2019 to 2020
$239k
NIDDK NIH HHS DK106427NIDDK NIH HHS DK120292NIDDK NIH HHS DK122137NIDDK NIH HHS DK122734NIDDK NIH HHS K08 DK106427NIDDK NIH HHS R01 DK120292NIDDK NIH HHS R01 DK122734NIDDK NIH HHS R03 DK122137
6 · The paper itself

Abstract

backgroundPercutaneous transluminal renal angioplasty (PTRA) confers clinical and mortality benefits in select 'high-risk' patients with renovascular disease (RVD). Intra-renal-delivered extracellular vesicles (EVs) released from mesenchymal stem/stromal cells (MSCs) protect the kidney in experimental RVD, but have not been compared side-by-side to clinically applied interventions, such as PTRA. We hypothesized that MSC-derived EVs can comparably protect the post-stenotic kidney via direct tissue effects.

methodsFive groups of pigs (

resultsDespite sustained hypertension, EVs conferred greater improvement of intra-renal microvascular and peritubular capillary density compared to PTRA, associated with attenuation of renal inflammation, oxidative stress, and tubulo-interstitial fibrosis. Nevertheless, stenotic kidney RBF and GFR similarly rose in both PTRA- and EV-treated pigs compared RVD + Sham. mRNA sequencing reveled that EVs were enriched with pro-angiogenic, anti-inflammatory, and antioxidants genes.

conclusionMSC-derived EVs elicit a better preservation of the stenotic kidney microvasculature and greater attenuation of renal injury and fibrosis compared to PTRA, possibly partly attributed to their cargo of vasculo-protective genes. Yet, both strategies similarly improve renal hemodynamics and function. These observations shed light on diverse mechanisms implicated in improvement of post-stenotic kidney function and position EVs as a promising therapeutic intervention in RVD.

Indexed as

Renal CirculationAnimalsExtracellular VesiclesFemaleHumansHuman Umbilical Vein Endothelial CellsInflammationKidneyKidney DiseasesMesenchymal Stem CellsMicrovesselsOxidative StressSwineextracellular vesiclesmesenchymal stem/stromal cellsmicrovasculaturerenovascular diseaserevascularization

Identifiers

PMID33807246
PMCPMC8103265
OpenAlexW3152278354

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.