Evidence map›Paper›PMID 33808129›Full record

ArticleInternational journal of molecular sciences2021

Defining Phenotype, Tropism, and Retinal Gene Therapy Using Adeno-Associated Viral Vectors (AAVs) in New-Born Brown Norway Rats with a Spontaneous Mutation in

Nanda Boon, C Henrique Alves, Aat A Mulder, Charlotte A Andriessen, Thilo M Buck, Peter M J Quinn, Rogier M Vos, Abraham J Koster, Carolina R Jost, Jan Wijnholds

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Diverse functions and pathogenetic role of Crumbs in retinopathy.Cell communication and signaling : CCS · 2024
    Review
  3. Article
  4. Proof-of-concept for multiple AON delivery by a single U7snRNA vector to restore splicing defects in ABCA4.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nanda BoonDepartment of Ophthalmology, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-9756-8898
C Henrique AlvesDepartment of Ophthalmology, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-9776-5701
Aat A MulderDepartment of Cell & Chemical Biology, Leiden University Medical Center (LUMC), 2300 RC Leiden, The Netherlands.
Charlotte A AndriessenDepartment of Ophthalmology, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Thilo M BuckDepartment of Ophthalmology, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-9594-1123
Peter M J QuinnDepartment of Ophthalmology, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-9940-4264
Rogier M VosDepartment of Ophthalmology, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Abraham J KosterDepartment of Cell & Chemical Biology, Leiden University Medical Center (LUMC), 2300 RC Leiden, The Netherlands.
Carolina R JostDepartment of Cell & Chemical Biology, Leiden University Medical Center (LUMC), 2300 RC Leiden, The Netherlands.ORCID 0000-0001-8342-1094
Jan WijnholdsDepartment of Ophthalmology, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands.ORCID 0000-0003-0099-460X
Leiden University Medical Center · NLNetherlands Institute for Neuroscience · NL

Funding

Bontius Stichting Bontius 23122019Dutch blindness funds Uitzicht 2013-13Dutch blindness funds Uitzicht 2018-6Foundation Fighting Blindness TA-GT-0715-0665-LUMCthe Netherlands Organization for Health Research and Development ZonMw grant 43200004
6 · The paper itself

Abstract

Mutations in the Crumbs homologue 1 (

Indexed as

AnimalsAnimals, NewbornCalcium-Binding ProteinsCarrier ProteinsDependovirusEpendymoglial CellsEye ProteinsGenetic TherapyGenetic VectorsIntravitreal InjectionsMembrane ProteinsMutationNerve Tissue ProteinsPhenotypeRatsRats, Mutant StrainsCalcium-Binding ProteinsCarrier ProteinsCRB1 protein, humancrb1 protein, ratCRB2 protein, humanEye ProteinsMembrane ProteinsNerve Tissue ProteinsAAV-mediated gene therapyAAV tropismCRB1CRB2Crumbs homologue 1retinitis pigmentosa

Identifiers

PMID33808129
PMCPMC8036486
OpenAlexW3145982762

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.