Evidence map›Paper›PMID 33808456›Full record

ArticleInternational journal of molecular sciences2021

Understanding the Molecular Basis of 5-HT

Alejandro Castro-Alvarez, Emigdio Chávez-Ángel, Ronald Nelson

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Low-Basicity 5-HTInternational journal of molecular sciences · 2024
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Alejandro Castro-AlvarezLaboratorio de Bioproductos Farmacéuticos y Cosméticos, Centro de Excelencia en Medicina Traslacional, Facultad de Medicina, Universidad de La Frontera, Av. Francisco Salazar 01145, Temuco 4780000, Chile.ORCID 0000-0001-8360-8027
Emigdio Chávez-ÁngelCatalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain.ORCID 0000-0002-9783-0806
Ronald NelsonDepartamento de Química, Facultad de Ciencias, Universidad Católica del Norte, Av. Angamos 0610, Antofagasta 1270709, Chile.ORCID 0000-0001-7449-6334
Institut Català de Nanociència i Nanotecnologia · ESUniversidad Católica del Norte · CLUniversidad de La Frontera · CL

Funding

Fondo Nacional de Desarrollo Científico y Tecnológico 11200620Fondo Nacional de Desarrollo Científico y Tecnológico 3190118
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder whose prevalence has an incidence in senior citizens. Unfortunately, current pharmacotherapy only offers symptom relief for patients with side effects such as bradycardia, nausea, and vomiting. Therefore, there is a present need to provide other therapeutic alternatives for treatments for these disorders. The 5-HT

Indexed as

Quantitative Structure-Activity RelationshipHumansModels, MolecularMolecular Docking SimulationReceptors, Serotonin, 5-HT4Serotonin 5-HT4 Receptor AgonistsSerotonin 5-HT4 Receptor AntagonistsStructure-Activity RelationshipReceptors, Serotonin, 5-HT4Serotonin 5-HT4 Receptor AgonistsSerotonin 5-HT4 Receptor Antagonists3D-QSAR5-HT4Alzheimer’s diseaseforce and gaussian fieldspartial agonist

Identifiers

PMID33808456
PMCPMC8036435
OpenAlexW3143313154

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.