Evidence mapPaperPMID 33808800Full record

ReviewInternational journal of molecular sciences2021

Recent Highlights of Research on miRNAs as Early Potential Biomarkers for Cardiovascular Complications of Type 2 Diabetes Mellitus.

Agnieszka Bielska, Magdalena Niemira, Adam Kretowski

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. MicroRNAs in diabetic macroangiopathy.Cardiovascular diabetology · 2024
    Review
  11. Article
  12. Review
  13. Glycemia-Induced miRNA Changes: A Review.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Agnieszka BielskaClinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, Poland.ORCID 0000-0002-2619-4494
Magdalena NiemiraClinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, Poland.ORCID 0000-0002-0701-4961
Adam KretowskiClinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, Poland.ORCID 0000-0002-4522-4978
Medical University of Białystok · PL

Funding

Medical University of Bialystok SUB/1/NN/21/001/4406
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) and its complications pose a serious threat to the life and health of patients around the world. The most dangerous complications of this disease are vascular complications. Microvascular complications of T2DM include retinopathy, nephropathy, and neuropathy. In turn, macrovascular complications include coronary artery disease, peripheral artery disease, and cerebrovascular disease. The currently used diagnostic methods do not ensure detection of the disease at an early stage, and they also do not predict the risk of developing specific complications. MicroRNAs (miRNAs) are small, endogenous, noncoding molecules that are involved in key processes, such as cell proliferation, differentiation, and apoptosis. Recent research has assigned them an important role as potential biomarkers for detecting complications related to diabetes. We suggest that utilizing miRNAs can be a routine approach for early diagnosis and prognosis of diseases and may enable the development of better therapeutic approaches. In this paper, we conduct a review of the latest reports demonstrating the usefulness of miRNAs as biomarkers in the vascular complications of T2DM.

Indexed as

BiomarkersAnimalsCardiovascular DiseasesDiabetes Mellitus, Type 2Gene Expression RegulationHumansMicroRNAsPrognosisTranscription, GeneticBiomarkersMicroRNAsbiomarkercardiovascularcomplicationsdiabetesmiRNA

Identifiers

PMID33808800
PMCPMC8003798
OpenAlexW3138945045

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.