Evidence map›Paper›PMID 33808872›Full record

ReviewAntioxidants (Basel, Switzerland)2021

Endothelium as a Source and Target of H

Valerio Ciccone, Shirley Genah, Lucia Morbidelli

Open access · goldAbstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Recent Advances in Molecular Research on Hydrogen Sulfide (HInternational journal of molecular sciences · 2022
    Pooled it
  3. Pooled it
  4. Unravelling the Therapeutic Potential of Cysteine for Cardiovascular Health.International journal of molecular sciences · 2026
    Review
  5. Article
  6. Review
  7. Cystathionine γ lyase deletion enhances corpus cavernosum contraction via thromboxane AAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. HMedComm · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Anti-Inflammatory Effect of the Natural HInternational journal of molecular sciences · 2022
    Article
  18. Vulnerable Atherosclerotic Plaque: Is There a Molecular Signature?International journal of molecular sciences · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Valerio CicconeDepartment of Life Sciences, University of Siena, Via A. Moro 2, 53100 Siena, Italy.ORCID 0000-0002-5374-9694
Shirley GenahDepartment of Life Sciences, University of Siena, Via A. Moro 2, 53100 Siena, Italy.
Lucia MorbidelliDepartment of Life Sciences, University of Siena, Via A. Moro 2, 53100 Siena, Italy.ORCID 0000-0001-8148-7049
University of Siena · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca 2017XP72RF
6 · The paper itself

Abstract

The vascular endothelium consists of a single layer of squamous endothelial cells (ECs) lining the inner surface of blood vessels. Nowadays, it is no longer considered as a simple barrier between the blood and vessel wall, but a central hub to control blood flow homeostasis and fulfill tissue metabolic demands by furnishing oxygen and nutrients. The endothelium regulates the proper functioning of vessels and microcirculation, in terms of tone control, blood fluidity, and fine tuning of inflammatory and redox reactions within the vessel wall and in surrounding tissues. This multiplicity of effects is due to the ability of ECs to produce, process, and release key modulators. Among these, gasotransmitters such as nitric oxide (NO) and hydrogen sulfide (H

Indexed as

angiogenesisatherosclerosisdiabetesendothelial dysfunctionH2S donorshydrogen sulfidehypertensionvascular endotheliumwound healing

Identifiers

PMID33808872
PMCPMC8003673
OpenAlexW3136444997

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.