Evidence map›Paper›PMID 33808990›Full record

SynthesisGenes2021

The Decisive Case-Control Study Elaborates the Null Association between

Yu-Hao Huang, Wen-Hui Fang, Dung-Jang Tsai, Yu-Hsuan Chen, Yu-Chiao Wang, Wen Su, Chung-Cheng Kao, Kevin Yi, Chih-Chien Wang, Sui-Lung Su

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Yu-Hao HuangGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan.
Wen-Hui FangDepartment of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Dung-Jang TsaiGraduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0002-5531-0810
Yu-Hsuan ChenSchool of Public Health, National Defense Medical Center, Taipei 11490, Taiwan.
Yu-Chiao WangSchool of Public Health, National Defense Medical Center, Taipei 11490, Taiwan.
Wen SuGraduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei 11490, Taiwan.
Chung-Cheng KaoSuperintendent's Office, Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Taipei 10581, Taiwan.
Kevin YiDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907-2063, USA.
Chih-Chien WangDepartment of Orthopedics, Tri-Service General Hospital and National Defense Medical Center, Taipei 11490, Taiwan.
Sui-Lung SuGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan.
National Defense Medical Center · TWTri-Service General Hospital · TWPurdue University West Lafayette · USTaoyuan Armed Forces General Hospital · TWTri-Service General Hospital Songshan Branch · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: The prevalence of knee osteoarthritis (OA) in women is significantly higher than in men. The estrogen receptor α (ERα) has been considered to play a key role due to a large gender difference in its expression. ERα is encoded by the gene estrogen receptor 1 (

Indexed as

AgedAllelesAsian PeopleCase-Control StudiesEstrogen Receptor alphaFemaleGenetic Predisposition to DiseaseHumansMaleOdds RatioOsteoarthritis, KneePolymorphism, GeneticRisk FactorsESR1 protein, humanEstrogen Receptor alphaESR1 XbaIestrogen receptor 1 (ESR1)meta-analysisosteoarthritis (OA)polymorphismrs9340799trial sequential analysis

Identifiers

PMID33808990
PMCPMC7999595
OpenAlexW3136591089

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.