Evidence map›Paper›PMID 33809132›Full record

ArticleGenes2021

Non-Target Effects of dsRNA Molecules in Hemipteran Insects.

Arinder K Arora, Seung Ho Chung, Angela E Douglas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Insects · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Silencing of ATP Synthase β Impairs Egg Development in the LeafhopperInternational journal of molecular sciences · 2022
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Arinder K AroraDepartment of Entomology, Cornell University, Ithaca, NY 14850, USA.
Seung Ho ChungDepartment of Entomology, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0003-4108-8320
Angela E DouglasDepartment of Entomology, Cornell University, Ithaca, NY 14850, USA.
Cornell University · US

Funding

California Department of Food and Agriculture 17-0416-000-SA and 19-0263-000-SANational Institute of Food and Agriculture GRANT12216941
6 · The paper itself

Abstract

Insect pest control by RNA interference (RNAi)-mediated gene expression knockdown can be undermined by many factors, including small sequence differences between double-stranded RNA (dsRNA) and the target gene. It can also be compromised by effects that are independent of the dsRNA sequence on non-target organisms (known as sequence-non-specific effects). This study investigated the species-specificity of RNAi in plant sap-feeding hemipteran pests. We first demonstrated sequence-non-specific suppression of aphid feeding by dsRNA at dietary concentrations ≥0.5 µg µL

Indexed as

AnimalsAphidsGene Knockdown TechniquesHemipteraInsect ProteinsRNA, Double-StrandedRNA InterferenceInsect ProteinsRNA, Double-StrandedAcyrthosiphon pisumBemisia tabaciMyzus persicaenon-target organismsnucleases of insectsplant sap-feeding insectsPseudococcus maritimusRNAi specificitysequence-non-specific RNAi

Identifiers

PMID33809132
PMCPMC8000911
OpenAlexW3137754583

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.