Evidence map›Paper›PMID 33809413›Full record

ReviewInternational journal of molecular sciences2021

Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke?

Nicolas Hugues, Christophe Pellegrino, Claudio Rivera, Eric Berton, Caroline Pin-Barre, Jérôme Laurin

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06292442 (Effects of High-Intensity Interval Training on Muscle Strength, Atrophy and Aerobic Capacity in Stroke Patients.), which is not on this map. Cited by 29 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 5 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06292442 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of High-Intensity Interval Training on Muscle Strength, Atrophy and Aerobic Capacity in Stroke Patients.

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2023Enrolled34ConditionsStrokeArmstraditional physical therapy, High intensity interval training
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nicolas HuguesINMED, INSERM, Aix-Marseille University, 13007 Marseille, France.
Christophe PellegrinoINMED, INSERM, Aix-Marseille University, 13007 Marseille, France.ORCID 0000-0002-0669-4918
Claudio RiveraINMED, INSERM, Aix-Marseille University, 13007 Marseille, France.
Eric BertonCNRS, ISM, Aix-Marseille University, 13007 Marseille, France.
Caroline Pin-BarreCNRS, ISM, Aix-Marseille University, 13007 Marseille, France.
Jérôme LaurinINMED, INSERM, Aix-Marseille University, 13007 Marseille, France.ORCID 0000-0001-9692-0060
Centre National de la Recherche Scientifique · FRInserm · FRUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke-induced cognitive impairments affect the long-term quality of life. High-intensity interval training (HIIT) is now considered a promising strategy to enhance cognitive functions. This review is designed to examine the role of HIIT in promoting neuroplasticity processes and/or cognitive functions after stroke. The various methodological limitations related to the clinical relevance of studies on the exercise recommendations in individuals with stroke are first discussed. Then, the relevance of HIIT in improving neurotrophic factors expression, neurogenesis and synaptic plasticity is debated in both stroke and healthy individuals (humans and rodents). Moreover, HIIT may have a preventive role on stroke severity, as found in rodents. The potential role of HIIT in stroke rehabilitation is reinforced by findings showing its powerful neurogenic effect that might potentiate cognitive benefits induced by cognitive tasks. In addition, the clinical role of neuroplasticity observed in each hemisphere needs to be clarified by coupling more frequently to cellular/molecular measurements and behavioral testing.

Indexed as

High-Intensity Interval TrainingCognitionHumansNeuronal PlasticityPhysical EnduranceRecovery of FunctionStrokeangiogenesiscerebral ischemiacognitionendurance exerciseneurogenesisneurotrophic factorsrat and human modelstroke rehabilitation

Identifiers

PMID33809413
PMCPMC7998434
OpenAlexW3136303130

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.