Evidence map›Paper›PMID 33809789›Full record

ArticlePharmaceutics2021

Genetically Encoded Self-Assembling Iron Oxide Nanoparticles as a Possible Platform for Cancer-Cell Tracking.

Maria V Efremova, Silviu-Vasile Bodea, Felix Sigmund, Alevtina Semkina, Gil G Westmeyer, Maxim A Abakumov

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Nanotechnological Applications Based on Bacterial Encapsulins.Nanomaterials (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Maria V EfremovaDepartment of Chemistry & TUM School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Silviu-Vasile BodeaDepartment of Chemistry & TUM School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Felix SigmundDepartment of Chemistry & TUM School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Alevtina SemkinaDepartment of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Gil G WestmeyerDepartment of Chemistry & TUM School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Maxim A AbakumovDepartment of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Helmholtz Zentrum München · DENational University of Science and Technology · RUPirogov Russian National Research Medical University · RUTechnical University of Munich · DE

Funding

Helmholtz-RSF Joint Research Groups funding program HRSF-0064Russian Science Foundation 19-45-06302
6 · The paper itself

Abstract

The study of growth and possible metastasis in animal models of tumors would benefit from reliable cell labels for noninvasive whole-organism imaging techniques such as magnetic resonance imaging. Genetically encoded cell-tracking reporters have the advantage that they are contrast-selective for viable cells with intact protein expression machinery. Besides, these reporters do not suffer from dilution during cell division. Encapsulins, which are bacterial protein nanocompartments, can serve as genetically controlled labels for multimodal detection of cells. Such nanocompartments can host various guest molecules inside their lumen. These include, for example, fluorescent proteins or enzymes with ferroxidase activity leading to biomineralization of iron oxide inside the encapsulin nanoshell. The aim of this work was to implement heterologous expression of encapsulin systems from

Indexed as

biogenic iron oxide nanoparticlescell trackingencapsulinsfluorescencegenetically controlled imaging reportersmagnetic resonance imagingvisualization of cancer cells

Identifiers

PMID33809789
PMCPMC8002387
OpenAlexW3139196242

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.