Evidence map›Paper›PMID 33809978›Full record

ArticleCells2021

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297-391) Intermediates.

Mahmoud B Maina, Youssra K Al-Hilaly, Gunasekhar Burra, Janet E Rickard, Charles R Harrington, Claude M Wischik, Louise C Serpell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Mahmoud B MainaSussex Neuroscience, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.ORCID 0000-0002-7421-3813
Youssra K Al-HilalySussex Neuroscience, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.ORCID 0000-0003-2289-4597
Gunasekhar BurraSussex Neuroscience, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.ORCID 0000-0001-5740-5760
Janet E RickardInstitute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZP, UK.
Charles R HarringtonInstitute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZP, UK.ORCID 0000-0003-2250-3920
Claude M WischikInstitute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZP, UK.
Louise C SerpellSussex Neuroscience, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.
University of Aberdeen · GBUniversity of Sussex · GBMustansiriyah University · IQ

Funding

Alzheimer's Society AS-PG-16b-010Biotechnology and Biological Sciences Research Council BB/S003657/1European Molecular Biology Organization EMBO-STF 7674Wellcome Trust
6 · The paper itself

Abstract

The self-assembly of tau into paired helical filaments (PHFs) in neurofibrillary tangles (NFTs) is a significant event in Alzheimer's disease (AD) pathogenesis. Numerous post-translational modifications enhance or inhibit tau assembly into NFTs. Oxidative stress, which accompanies AD, induces multiple post-translational modifications in proteins, including the formation of dityrosine (DiY) cross-links. Previous studies have revealed that metal-catalysed oxidation (MCO) using Cu

Indexed as

Oxidative StressProtein Processing, Post-TranslationalCell Line, TumorChelating AgentsCopperEdetic AcidHumansHydrogen PeroxideNeuronsOxidantsPeptide FragmentsProtein Conformation, beta-StrandProtein MultimerizationReactive Oxygen SpeciesSolubilityStructure-Activity RelationshipChelating AgentsCopperEdetic AcidHydrogen PeroxideMAPT protein, humanOxidantsPeptide FragmentsReactive Oxygen Speciestau ProteinsAlzheimer’s diseasedityrosineoxidative stresspaired helical filamentstau

Identifiers

PMID33809978
PMCPMC8005035
OpenAlexW3138637436

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.