Evidence map›Paper›PMID 33810231›Full record

ArticleLife (Basel, Switzerland)2021

Immunoreactivity of Muscarinic Acetylcholine M2 and Serotonin 5-HT2B Receptors, Norepinephrine Transporter and Kir Channels in a Model of Epilepsy.

Enes Akyuz, Zuleyha Doganyigit, Yam Nath Paudel, Betul Koklu, Emin Kaymak, Chiara Villa, Alina Arulsamy, Mohd Farooq Shaikh, Orrin Devinsky

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Enes AkyuzDepartment of Biophysics, Faculty of International Medicine, University of Health Sciences, Istanbul 34668, Turkey.ORCID 0000-0002-3942-2097
Zuleyha DoganyigitDepartment of Histology and Embryology, Faculty of Medicine, Yozgat Bozok University, Yozgat 66100, Turkey.
Yam Nath PaudelNeuropharmacology Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Selangor, Malaysia.ORCID 0000-0002-8804-6331
Betul KokluFaculty of Medicine, Yozgat Bozok University, Yozgat 66100, Turkey.
Emin KaymakDepartment of Histology and Embryology, Faculty of Medicine, Yozgat Bozok University, Yozgat 66100, Turkey.
Chiara VillaSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0003-2730-5974
Alina ArulsamyNeuropharmacology Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Selangor, Malaysia.ORCID 0000-0003-0993-5622
Mohd Farooq ShaikhNeuropharmacology Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Selangor, Malaysia.ORCID 0000-0001-9865-6224
Orrin DevinskyComprehensive Epilepsy Center, Department of Neurology, NYU Langone School of Medicine, New York, NY 10010, USA.ORCID 0000-0003-0044-4632
Monash University Malaysia · MYYozgat Bozok Üniversitesi · TRSağlık Bilimleri Üniversitesi · TRUniversity of Milano-Bicocca · IT

Funding

Yozgat Bozok University 6602c-TF/19-299
6 · The paper itself

Abstract

Epilepsy is characterized by an imbalance in neurotransmitter activity; an increased excitatory to an inhibitory activity. Acetylcholine (ACh), serotonin, and norepinephrine (NE) may modulate neural activity via several mechanisms, mainly through its receptors/transporter activity and alterations in the extracellular potassium (K

Indexed as

5-HT2Bchronic epilepsyM2norepinephrinePTZ

Identifiers

PMID33810231
PMCPMC8066555
OpenAlexW3137691746

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.