Evidence map›Paper›PMID 33812373›Full record

SynthesisCardiovascular diabetology2021

Triglyceride-glucose index and the incidence of atherosclerotic cardiovascular diseases: a meta-analysis of cohort studies.

Xiaobo Ding, Xiaozhen Wang, Jing Wu, Manli Zhang, Meizi Cui

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cardiovascular diabetology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 274 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
274citing papers in PubMed, 12 pooled it
52.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

274 citing papers in PubMed, 12 syntheses or guidelines pooled it, 477 citations in OpenAlex.

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214 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiaobo Ding *Radiology Department, The First Hospital of Jilin University, Changchun, 130021, China.
Xiaozhen Wang *Department of Breast Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
Jing WuDepartment of General Practice, The First Hospital of Jilin University, Changchun, 130021, China.
Manli ZhangDepartment of Hepatology and Gastroenterology, The Second Part of First Hospital, Jilin University, Changchun, 130021, China.
Meizi CuiDepartment of Cadre Ward, The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130021, China. chlalwk@jlu.edu.cn.
Jilin University · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInsulin resistance has been demonstrated to be involved in the pathogenesis of atherosclerotic cardiovascular diseases (ASCVDs). This study evaluated the association between the triglyceride-glucose (TyG) index, a novel surrogate indicator of insulin resistance, and the incidence of ASCVDs in people without ASCVDs at baseline by performing a meta-analysis.

methodsCohort studies reporting the multivariate-adjusted association between the TyG index and the incidence of ASCVDs were obtained by searching the PubMed and Embase databases. A random-effects model incorporating intra-study heterogeneity was applied to combine the results.

resultsEight cohort studies comprising 5,731,294 participants were included in this meta-analysis. The results showed that compared to those with the lowest TyG index category, participants with the highest TyG index category were independently associated with a higher risk of ASCVDs [hazard ratio (HR): 1.61, 95% confidence interval (CI) 1.29-2.01, I

conclusionsA higher TyG index may be independently associated with a higher incidence of ASCVDs, CAD, and stroke in people without ASCVDs at baseline.

Indexed as

Insulin ResistanceAgedAtherosclerosisBiomarkersBlood GlucoseCoronary Artery DiseaseFemaleHumansIncidenceMaleMiddle AgedRisk AssessmentRisk FactorsStrokeTime FactorsTriglyceridesBiomarkersBlood GlucoseTriglyceridesAtherosclerotic cardiovascular diseasesCoronary artery diseaseInsulin resistanceMeta-analysisTriglyceride-glucose index

Identifiers

PMID33812373
PMCPMC8019501
OpenAlexW3147389358

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.