Evidence map›Paper›PMID 33815409›Full record

ArticleFrontiers in immunology2021

Hua Ye, Tiandong Li, Hua Wang, Jinyu Wu, Chuncheng Yi, Jianxiang Shi, Peng Wang, Chunhua Song, Liping Dai, Guozhong Jiang and 3 more

Open access · goldAbstract readValidation Study
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Hua YeCollege of Public Health, Zhengzhou University, Zhengzhou, China.
Tiandong LiCollege of Public Health, Zhengzhou University, Zhengzhou, China.
Hua WangCollege of Public Health, Zhengzhou University, Zhengzhou, China.
Jinyu WuCollege of Public Health, Zhengzhou University, Zhengzhou, China.
Chuncheng YiCollege of Public Health, Zhengzhou University, Zhengzhou, China.
Jianxiang ShiHenan Key Laboratory of Tumor Epidemiology, Zhengzhou, China.
Peng WangCollege of Public Health, Zhengzhou University, Zhengzhou, China.
Chunhua SongCollege of Public Health, Zhengzhou University, Zhengzhou, China.
Liping DaiHenan Key Laboratory of Tumor Epidemiology, Zhengzhou, China.
Guozhong JiangDeparment of Pathology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yuxin HuangProgram in Public Health, University of California, Irvine, Irvine, CA, United States.
Yongwei YuDepartment of Pathology, Second Military Medical University, Shanghai, China.
Jitian LiLaboratory of Molecular Biology, Henan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, China.
Zhengzhou University · CNLuoyang Orthopedic-Traumatological Hospital of Henan Province · CNFirst Affiliated Hospital of Zhengzhou University · CNSecond Military Medical University · CNUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer is a lethal malignancy with a poor prognosis. This study aims to identify pancreatic cancer-related genes and develop a robust diagnostic model to detect this disease. Weighted gene co-expression network analysis (WGCNA) was used to determine potential hub genes for pancreatic cancer. Their mRNA and protein expression levels were validated through reverse transcription PCR (RT-PCR) and immunohistochemical (IHC). Diagnostic models were developed by eight machine learning algorithms and ten-fold cross-validation. Four hub genes (

Indexed as

Gene Expression Regulation, NeoplasticModels, GeneticAldehyde OxidoreductasesBiomarkers, TumorCathepsin EComputational BiologyDatasets as TopicGene Expression ProfilingGene Regulatory NetworksHumansMachine LearningMembrane ProteinsOligonucleotide Array Sequence AnalysisPancreasPancreatic NeoplasmsProtein Interaction MapsAldehyde OxidoreductasesBiomarkers, TumorCathepsin ECTSE protein, humanMembrane ProteinsSDR16C5 protein, humanSerine EndopeptidasesTetraspaninsTMPRSS4 protein, humanTSPAN1 protein, humanbioinformaticsdiagnostic modelmachine learningpancreatic cancerpanelWGCNA

Identifiers

PMID33815409
PMCPMC8015801
OpenAlexW3139495760

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.