Evidence map›Paper›PMID 33818699›Full record

ArticleGenes & genomics2022

Identification of MicroRNAs as potential biomarkers for detecting ischemic stroke.

Kexin Li, Li Shen, Pingping Zheng, Yanjun Wang, Lijuan Wang, Xiaoli Meng, Yaogai Lv, Zhiqiang Xue, Xin Guo, Anning Zhang and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Genes & genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Role of miRNAs in neurovascular injury and repair.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Review
  4. Article
  5. circRNA fromInternational journal of molecular sciences · 2023
    Article
  6. Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Kexin Li *Epidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, ChangchunJilin, 130021, China.
Li Shen *Department of Hospital Infection Management, Zhengzhou People's Hospital, Zhengzhou, 450000, China.
Pingping ZhengEpidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, ChangchunJilin, 130021, China.
Yanjun WangNursing Department, The Second Hospital of Jilin University, ChangchunJilin, 130021, China.
Lijuan WangDepartment of Neurology, The Neuroscience Center, The First Hospital of Jilin University, Changchun, 130021, China.
Xiaoli MengNursing Department, The Second Hospital of Jilin University, ChangchunJilin, 130021, China.
Yaogai LvEpidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, ChangchunJilin, 130021, China.
Zhiqiang XueEpidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, ChangchunJilin, 130021, China.
Xin GuoDepartment of Radiation, China-Japan Union Hospital of Jilin University, ChangchunJilin, 130021, China.
Anning ZhangEpidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, ChangchunJilin, 130021, China.
Pan PanEpidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, ChangchunJilin, 130021, China.
Chunli BiEpidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, ChangchunJilin, 130021, China.
Yang ChenEpidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, ChangchunJilin, 130021, China.
Tianyu FengEpidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, ChangchunJilin, 130021, China.
Bo LiEpidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, ChangchunJilin, 130021, China.
Lina JinEpidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, ChangchunJilin, 130021, China. jinln@jlu.edu.cn.
Yan YaoEpidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, ChangchunJilin, 130021, China. yaoyan@jlu.edu.cn.
Jilin University · CNSecond Affiliated Hospital of Jilin University · CNZhengzhou People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreasing epidemic of ischemic stroke (IS) makes it urgent to understand the pathogenesis and regulatory mechanism, previous studies have described microRNAs (miRNAs) is part of the brain's response to ischemia.

objectiveThe aim of this study was to screen potential biomarkers for the prediction and novel treatment of IS.

methodsDifferentially expressed miRNAs were screened from three newly diagnosed IS patients and three controls by RNA sequencing technology. Furthermore, target prediction databases were then used to analysis the target genes of different expressed miRNAs, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database were used to identify the functions and the main biochemical and signal pathways of differentially expressed target genes.

resultsOur results revealed that 27 miRNAs were differentially expressed in IS, among which, hsa-miR-659-5p was the most highly increased and was first found to be associated with IS. In addition, KEGG pathway analyses showed that differentially expressed miRNAs were mainly significantly enriched in lysosome pathway, cytokine-cytokine receptor interaction pathway, spliceosome pathway, base excision repair pathway.

conclusionsmiRNAs were involved in IS pathogenesis, and hsa-miR-659-5p, hsa-miR-151a-3p and hsa-miR-29c-5p as the three highest |log2FoldChange| regulation in this study, which may be the biomarkers of IS and need further study.

Indexed as

Gene Expression ProfilingBiomarkersCluster AnalysisGene Regulatory NetworksHumansIschemic StrokeMaleMicroRNAsMiddle AgedSequence Analysis, RNASignal TransductionBiomarkersMicroRNAsMIRN151a microRNA, humanMIRN29C microRNA, humanMIRN659 microRNA, humanBiomarkerDifferential expression analysisIschemic strokeKEGGmicroRNAs

Identifiers

PMID33818699
OpenAlexW3143043746

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.