Evidence map›Paper›PMID 33820494›Full record

ArticleCancer biology & therapy2021

Discovery of a rare

Lily Deland, Simon Keane, Thomas Olsson Bontell, Helene Sjögren, Henrik Fagman, Ingrid Øra, Esther De La Cuesta, Magnus Tisell, Jonas A Nilsson, Katarina Ejeskär and 2 more

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Cancer biology & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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  11. NovelCancer genomics & proteomics
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Lily DelandDepartment of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID 0000-0003-0338-4911
Simon KeaneTranslational Medicine, School of Health Sciences, University of Skövde, Skövde, Sweden.ORCID 0000-0002-0471-6896
Thomas Olsson BontellDepartment of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Helene SjögrenDepartment of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.
Henrik FagmanDepartment of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID 0000-0001-5853-6295
Ingrid ØraDepartment of Clinical Sciences, Lund University Hospital, Lund, Sweden.ORCID 0000-0002-3931-4125
Esther De La CuestaPharmaceuticals, Global Medical Affairs - Oncology, Bayer U.S., Whippany, USA.
Magnus TisellDepartment of Clinical Neuroscience and Rehabilitation, Sahlgrenska University Hospital, Gothenburg, Sweden.
Jonas A NilssonSahlgrenska Cancer Center, Department of Laboratory Medicine Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0003-0346-6837
Katarina EjeskärTranslational Medicine, School of Health Sciences, University of Skövde, Skövde, Sweden.
Magnus SabelChildhood Cancer Centre, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID 0000-0002-3072-657X
Frida AbelDepartment of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID 0000-0001-6958-4487
Sahlgrenska University Hospital · SEUniversity of Skövde · SEBayer (United States) · USKarolinska University Hospital · SENational Academy of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we report a case of an 11-year-old girl with an inoperable tumor in the optic chiasm/hypothalamus, who experienced several tumor progressions despite three lines of chemotherapy treatment. Routine clinical examination classified the tumor as a

Indexed as

Adaptor Proteins, Signal TransducingBrain NeoplasmsChildFemaleGliomaHumansHypothalamic DiseasesMembrane GlycoproteinsNeoplasm GradingOncogene Proteins, FusionOptic ChiasmProtein Kinase InhibitorsPyrazolesPyrimidinesReceptor, trkBAdaptor Proteins, Signal TransducinglarotrectinibMembrane GlycoproteinsOncogene Proteins, FusionProtein Kinase InhibitorsPyrazolesPyrimidinesReceptor, trkBtropomyosin-related kinase-B, humanGKAP1larotrectinibNTRK2pediatric brain tumorpLGGprecision medicineTRKB; fusion gene

Identifiers

PMID33820494
PMCPMC8043191
OpenAlexW3143940109

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.