Evidence map›Paper›PMID 33823779›Full record

ReviewCurrent neurovascular research2021

Alcohol Drinking, Apolipoprotein Polymorphisms and the Risk of Cardiovascular Diseases.

Flavio M Ceci, Mauro Ceccanti, Carla Petrella, Mario Vitali, Marisa P Messina, George N Chaldakov, Antonio Greco, Massimo Ralli, Marco Lucarelli, Antonio Angeloni and 2 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current neurovascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Alcohol Consumption and Autoimmune Diseases.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Flavio M CeciDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Mauro CeccantiSitac, Societa' Italiana per lo Studio delle Patologie Alcool Derivate. Rome, Italy.
Carla PetrellaInstitute of Biochemistry and Cell Biology, Section of Neurobiology, (IBBC-CNR), Rome, Italy.
Mario VitaliASUR Marche, AV4, Ancona, Italy.
Marisa P MessinaDepartment of Gynecology, Obstetric, and Urology, Sapienza University of Rome, Italy.
George N ChaldakovDepartment of Anatomy and Cell Biology, Medical University, and Institute for Advanced Study, Varna, Bulgaria.
Antonio GrecoDepartment of Sense Organs, Medical faculty, Sapienza University of Rome, Rome, Italy.
Massimo RalliDepartment of Sense Organs, Medical faculty, Sapienza University of Rome, Rome, Italy.
Marco LucarelliDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Antonio AngeloniDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Marco FioreInstitute of Biochemistry and Cell Biology, Section of Neurobiology, (IBBC-CNR), Rome, Italy.
Giampiero FerragutiDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITInstitute of Cell Biology and Neurobiology · ITCentre for Advanced Study · BGMarche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoprotein disorders are a major risk factor for atherosclerotic neuro-cardiovascular disease (ACVD) and are heavily influenced by lifestyle, including alcohol drinking. Moderate drinkers have a lower ACVD risk than abstainers due to their higher levels of high-density lipoprotein (HDL) cholesterol, an important protective factor against ACVD. On the contrary, heavy drinking increases ACVD risk. According to an extensive literature body, ethanol intoxication modifies lipid serum profile and induces endothelial dysfunction. Single nucleotide polymorphisms may influence the relationship between alcohol drinking, HDL cholesterol level, and atherosclerotic risk. The risk of ACVD in heavy drinkers seems enhanced in patients with apolipoprotein E4 allele, interleukin- 6-174 polymorphism, and cholesteryl ester transfer protein TaqIB polymorphism. Apolipoprotein E4 is a known risk factor for ACVD, while apolipoprotein E2 has mixed effects. Therefore, even if a "protective role" may be attributed to moderate drinking, this effect cannot be extended to everyone.

Indexed as

Polymorphism, Single NucleotideAlcohol DrinkingApolipoproteinsCardiovascular DiseasesGenetic Predisposition to DiseaseHumansApolipoproteinsadiponectin.Alcoholismapolipoprotein Eatherosclerotic cardiovascular diseasegenetic polymorphism

Identifiers

PMID33823779
PMCPMC8778646
OpenAlexW3141091799

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.