Evidence map›Paper›PMID 33823925›Full record

SynthesisStem cell research & therapy2021

Mesenchymal stromal/stem cells and their exosomes for restoration of spermatogenesis in non-obstructive azoospermia: a systemic review.

Rano Zhankina, Neda Baghban, Manarbek Askarov, Dana Saipiyeva, Almaz Ibragimov, Bakhyt Kadirova, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Ulanbek Zhanbyrbekuly and 1 more

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Stem cell research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Recent Progress of Induced Spermatogenesis In Vitro.International journal of molecular sciences · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Articles in the field of infertility (2013-2022): a bibliometric analysis.Journal of assisted reproduction and genetics · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Rano Zhankina *Department of Urology and Andrology, Astana Medical University, Nur-Sultan, Kazakhstan, 010000.
Neda Baghban *The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, 7514633196, Iran.
Manarbek AskarovDepartment of Urology and Andrology, Astana Medical University, Nur-Sultan, Kazakhstan, 010000.
Dana SaipiyevaDepartment of Urology and Andrology, Astana Medical University, Nur-Sultan, Kazakhstan, 010000.
Almaz IbragimovDepartment of Urology and Andrology, Astana Medical University, Nur-Sultan, Kazakhstan, 010000.
Bakhyt KadirovaDepartment of Urology and Andrology, Astana Medical University, Nur-Sultan, Kazakhstan, 010000.
Arezoo KhoradmehrThe Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, 7514633196, Iran.
Iraj NabipourThe Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, 7514633196, Iran.
Reza ShiraziDepartment of Anatomy, School of Medical Sciences, Medicine, UNSW Sydney, PO Box 2052, Sydney, Australia. reza.shirazi@unsw.edu.au.
Ulanbek ZhanbyrbekulyDepartment of Urology and Andrology, Astana Medical University, Nur-Sultan, Kazakhstan, 010000. ulanbek.amu@gmail.com.
Amin TamadonThe Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, 7514633196, Iran. amintamaddon@yahoo.com.ORCID 0000-0002-0222-3035
Astana Medical University · KZBiotechnology Research Center · IRUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cells have been introduced as new promising therapeutic agents in treatment of degenerative diseases because of having high differentiation potential while maintaining the ability to self-replicate and retaining features of their source cells. Among different type of cell therapies, mesenchymal stromal/stem cell (MSC) therapy is being increasingly developed as a new way to treat structural defects that need to be repaired and regenerated. Non-obstructive azoospermia (NOA) is a reproductive disease in men that causes infertility in 10% of infertile men. Based on in vitro studies, MSCs from different tissue sources have been differentiated into germ cells or gamete progenitor cells by simple methods in both male and female. On the other hand, the therapeutic effects of MSCs have been evaluated for the treatment of NOA animal models created by chemical or surgical compounds. The results of these studies confirmed successful allotransplantation or xenotransplantation of MSCs in the seminiferous tubules. As well, it has been reported that exosomes secreted by MSCs are able to induce the process of spermatogenesis in the testes of infertile animal models. Despite numerous advances in the treatment of reproductive diseases in men and women with the help of MSCs or their exosomes, no clinical trial has been terminated on the treatment of NOA. This systematic review attempts to investigate the possibility of MSC therapy for NOA in men.

Indexed as

AzoospermiaExosomesAnimalsFemaleHumansMaleSpermatogenesisStem CellsTestisAnimal modelClinical trialInfertilityIn vitro studyMesenchymal stromal/stem cellNon-obstructive azoospermia

Identifiers

PMID33823925
PMCPMC8025392
OpenAlexW3144076044

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.