Evidence map›Paper›PMID 33823944›Full record

ArticleActa neuropathologica communications2021

Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes.

Xiaoyun Xu, Matthew Cowan, Flavio Beraldo, Amy Schranz, Patrick McCunn, Nicole Geremia, Zalman Brown, Maitray Patel, Karen L Nygard, Reza Khazaee and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 1 institution in 1 country.

Xiaoyun XuTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Matthew CowanTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Flavio BeraldoTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Amy SchranzTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Patrick McCunnTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Nicole GeremiaTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Zalman BrownDepartment of Computer Science, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Maitray PatelDepartment of Computer Science, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Karen L NygardThe Biotron Experimental Climate Change Research Centre, The University of Western Ontario, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Reza KhazaeeThe Biotron Experimental Climate Change Research Centre, The University of Western Ontario, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Lihong LuDepartment of Mechanical and Materials Engineering, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Xingyu LiuDepartment of Mechanical and Materials Engineering, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Michael J StrongTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Gregory A DekabanMolecular Medicine Research Laboratories, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Ravi MenonTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Robert BarthaTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Mark DaleyDepartment of Computer Science, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Haojie MaoDepartment of Mechanical and Materials Engineering, Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Vania PradoTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Marco A M PradoTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Lisa SaksidaTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Tim BusseyTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada.
Arthur BrownTranslational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street North, London, ON, N6A 5B7, Canada. abrown@robarts.ca.ORCID 0000-0002-8725-3195
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously reported long-term changes in the brains of non-concussed varsity rugby players using magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI) and functional magnetic imaging (fMRI). Others have reported cognitive deficits in contact sport athletes that have not met the diagnostic criteria for concussion. These results suggest that repetitive mild traumatic brain injuries (rmTBIs) that are not severe enough to meet the diagnostic threshold for concussion, produce long-term consequences. We sought to characterize the neuroimaging, cognitive, pathological and metabolomic changes in a mouse model of rmTBI. Using a closed-skull model of mTBI that when scaled to human leads to rotational and linear accelerations far below what has been reported for sports concussion athletes, we found that 5 daily mTBIs triggered two temporally distinct types of pathological changes. First, during the first days and weeks after injury, the rmTBI produced diffuse axonal injury, a transient inflammatory response and changes in diffusion tensor imaging (DTI) that resolved with time. Second, the rmTBI led to pathological changes that were evident months after the injury including: changes in magnetic resonance spectroscopy (MRS), altered levels of synaptic proteins, behavioural deficits in attention and spatial memory, accumulations of pathologically phosphorylated tau, altered blood metabolomic profiles and white matter ultrastructural abnormalities. These results indicate that exceedingly mild rmTBI, in mice, triggers processes with pathological consequences observable months after the initial injury.

Indexed as

AnimalsBehavior, AnimalBrainBrain ConcussionMaleMiceMice, Inbred C57BL5-Choice serial reaction time testConcussionExperimental brain injuryMagnetic resonance imagingMetabolomicsTauopathyTraumatic encephalopathyWhite matter pathology

Identifiers

PMID33823944
PMCPMC8025516
OpenAlexW3147199143

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.