Evidence map›Paper›PMID 33824207›Full record

ArticlemBio2021

Human Cytomegalovirus miR-US25-1 Targets the GTPase RhoA To Inhibit CD34

Nicole L Diggins, Lindsey B Crawford, Meaghan H Hancock, Jennifer Mitchell, Jay A Nelson

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Viral miRNA regulation of host gene expression.Seminars in cell & developmental biology · 2023
    Review
  7. Review
  8. Review
  9. Hematopoietic stem cells and betaherpesvirus latency.Frontiers in cellular and infection microbiology · 2023
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Evasion of the Host Immune Response by Betaherpesviruses.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicole L DigginsVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.ORCID 0000-0001-8007-7865
Lindsey B CrawfordVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.ORCID 0000-0003-1248-253X
Meaghan H HancockVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.ORCID 0000-0003-2945-0147
Jennifer MitchellVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Jay A NelsonVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA nelsonj@ohsu.edu.
Oregon Health & Science University · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
The Administrative CoreP01AI127335 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Patrizia Caposio · 2017 to 2026
$24.6M
Molecular Aspects of Cytomegalovirus LatencyR37AI021640 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HANCOCK, MEAGHAN H · 2018 to 2024
$4.0M
HCMV miRNA Regulation of Secretion and Formation of the Viral Assembly CompartmentR01AI120619 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS, NELSON, JAY A · 2016 to 2020
$3.9M
NIAID NIH HHS P01 AI127335NIAID NIH HHS R01 AI120619NIAID NIH HHS R37 AI021640NIH HHS P51 OD011092
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) microRNAs play essential roles in latency and reactivation in CD34

Indexed as

Genome, ViralHost-Pathogen InteractionsAntigens, CD34Cell ProliferationCytomegalovirusDown-RegulationGene Expression RegulationHEK293 CellsHematopoietic Stem CellsHumansMicroRNAsMitosisrhoA GTP-Binding ProteinSignal TransductionVirus LatencyAntigens, CD34MicroRNAsrhoA GTP-Binding ProteinRHOA protein, humanCD34+ hematopoietic progenitor cellshuman cytomegaloviruslatencymiRNARhoA

Identifiers

PMID33824207
PMCPMC8092260
OpenAlexW3146908580

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.