Evidence map›Paper›PMID 33826235›Full record

ArticlePediatric blood & cancer2021

Pleuropulmonary blastoma in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations.

Gianni Bisogno, Sabine Sarnacki, Teresa Stachowicz-Stencel, V Minard Colin, Andrea Ferrari, Jan Godzinski, Marion Gauthier Villars, Ewa Bien, Frederic Hameury, Sylvie Helfre and 16 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Pediatric blood & cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03382158 (International Pleuropulmonary Blastoma/DICER1 Registry), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03382158 recruitingnot on this map

International Pleuropulmonary Blastoma/DICER1 Registry (for PPB, DICER1 and Associated Conditions)

Typeobservational_patient_registrySponsorChildren's Hospitals and Clinics of MinnesotaRan2016 to 2035Enrolled3,400ConditionsPleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor, DICER1 Syndrome, Cystic Nephroma
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

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  8. Paediatric very rare tumours registration and management in European countries with low health expenditure average rates.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 20 institutions in 15 countries.

Gianni BisognoHematology-Oncology Division, Department of Women's and Children's Health, Padova University Hospital, Padua, Italy.ORCID 0000-0003-4462-5523
Sabine SarnackiDepartment of Pediatric Surgery, Hôpital Necker-Enfants Malades, Université de Paris, Paris, France.
Teresa Stachowicz-StencelDepartment of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Gdansk, Poland.
V Minard ColinDepartment of Paediatric and Adolescent Oncology, INSERM U1015, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Andrea FerrariPediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID 0000-0002-4724-0517
Jan GodzinskiDepartment of Pediatric Surgery, Marciniak Hospital, Wroclaw, Poland.
Marion Gauthier VillarsDepartment of Genetics, Institut Curie, Paris Sciences Lettres Research University, Paris, France.
Ewa BienDepartment of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Gdansk, Poland.
Frederic HameuryDepartment of Pediatric Surgery, Hôpital Femme Mère Enfant, Lyon, France.
Sylvie HelfreRadiotherapy Department, Institut Curie, Paris, France.
Dominik T SchneiderClinic of Pediatrics, Dortmund Municipal Hospital, Dortmund, Germany.ORCID 0000-0001-8153-1601
Yves ReguerrePediatric Hematology-Oncology Department, Centre Hospitalier Universitaire, Saint-Denis de La Réunion, Saint-Denis, France.
Ricardo Lopez AlmarazPediatric Oncology-Hematology Unit, University Hospital of Cruces, Barakaldo-Bizkaia, Spain.
Dragana JanicDepartment of Hematology and Oncology, University Children's Hospital, University of Belgrade, Belgrade, Serbia.
Maja CesenUniversity Medical Centre, Ljubljana, Slovenia.ORCID 0000-0003-2434-8960
Alexandra KolenovaDepartment of Pediatric Hematology and Oncology, National Institute of Children's Diseases and Comenius University Bratislava, Bratislava, Slovakia.
Jelena RasconClinic of Pediatrics, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Kata MartinovaDepartment of Hematology and Oncology, University Clinic for Children's Diseases, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, North Macedonia.
Rodica CosnaroviciOncopediatric Department, Oncology Institute "Prof. Dr. Ion Chiricuta,", Cluj-Napoca, Romania.
Apostolos PourtsidisOncology Department, P. and A. Kyriakou Children's Hospital, Athens, Greece.
Tal Ben AmiPediatric Hematology Unit, Kaplan Medical Center, Rehovot, Israel.
Jelena RoganovicDepartment of Pediatrics, Clinical Hospital Center Rijeka, University of Rijeka, Rijeka, Croatia.
Ewa KoscielniakPediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart - Olgahospital, Stuttgart Cancer Center, Stuttgart, Germany.ORCID 0000-0002-1519-7569
Kris Ann P SchultzInternational PPB/DICER1 Registry, Cancer and Blood Disorders, Children's Minnesota, Minneapolis, Minnesota, USA.
Ines B BrechtPediatric Hematology and Oncology, Children's Hospital, Eberhard-Karls-Universitaet Tuebingen, Tuebingen, Germany.
Daniel OrbachSIREDO Oncology Center (Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer), Institut Curie, PSL University, Paris, France.ORCID 0000-0002-2520-139X
Gdańsk Medical University · PLUniversité Paris Sciences et Lettres · FRCentre Hospitalier Universitaire de La Réunion · FRChildren’s Minnesota - St. Paul Hospital · USComenius University Bratislava · SKFondazione IRCCS Istituto Nazionale dei Tumori · ITHôpital Femme Mère Enfant · FRHôpital Necker-Enfants Malades · FRHospital de Cruces · ESInserm · FRInstitut Curie · FRInstitute of Oncology Prof. Dr. Ion Chiricuta · ROKaplan Medical Center · ILKlinikum Dortmund · DELjubljana University Medical Centre · SIOlgahospital · DEPanagiotis & Aglaia Kyriakou Children's Hospital · GRSs. Cyril and Methodius University in Skopje · MKSzpital im Tadeusza Marciniaka · PLUniversity Children's Hospital Tübingen · DE

Funding

Detecting DICER1: A global partnership to cure pediatric lung cancerR37CA244940 · NCI · CHILDREN'S HOSPITALS AND CLINICS · PI Kris Ann Pinekenstein Schultz · 2020 to 2026
$2.4M
NCI NIH HHS R37 CA244940
6 · The paper itself

Abstract

Pleuropulmonary blastoma (PPB) is a rare cancer occurring mainly during early childhood and often associated with germline DICER1 mutations. It is classified by the macroscopic appearance into three interrelated clinico-pathologic entities on a developmental continuum. Complete tumor resection is a main prognostic factor and can be performed at diagnosis or after neoadjuvant treatment that includes chemotherapy and in some cases radiotherapy. Optimal modalities of neo- or adjuvant treatments can be challenging taking into account potential long-term toxicities in this young population. This paper presents the recommendations for diagnosis and treatment of children and adolescents with PPB elaborated by the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT) within the European Union-funded project PARTNER (Paediatric Rare Tumours Network - European Registry).

Indexed as

Lung NeoplasmsPulmonary BlastomaAdolescentChildChild, PreschoolDEAD-box RNA HelicasesHumansNeoadjuvant TherapyRegistriesRibonuclease IIIDEAD-box RNA HelicasesDICER1 protein, humanRibonuclease IIIchildrenPARTNERpleuropulmonary blastomatherapeutic recommendationsvery rare tumors

Identifiers

PMID33826235
PMCPMC9813943
OpenAlexW3145354796

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.