Evidence map›Paper›PMID 33828444›Full record

ArticleFrontiers in neuroscience2021

A New Platinum-Based Prodrug Candidate for Chemotherapy and Its Synergistic Effect With Hadrontherapy: Novel Strategy to Treat Glioblastoma.

Beatrice Ferrari, Elisa Roda, Erica Cecilia Priori, Fabrizio De Luca, Angelica Facoetti, Mauro Ravera, Federico Brandalise, Carlo Alessandro Locatelli, Paola Rossi, Maria Grazia Bottone

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Current Advances in Nanocarriers for Cancer Therapy.International journal of nanomedicine · 2025
    Review
  7. Olive mill wastewater: From by-product to smart antioxidant material.International journal of pharmaceutics: X · 2024
    Article
  8. Article
  9. A Phyto-mycotherapeutic Supplement, NamelyInternational journal of molecular sciences · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Beatrice FerrariDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Elisa RodaDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Erica Cecilia PrioriDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Fabrizio De LucaDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Angelica FacoettiNational Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
Mauro RaveraDepartment of Sciences and Technological Innovation (DiSIT), University of Piemonte Orientale "A. Avogadro", Alessandria, Italy.
Federico BrandaliseDepartment of Fundamental Neurosciences (NEUFO), University of Geneva, Geneva, Switzerland.
Carlo Alessandro LocatelliLaboratory of Clinical & Experimental Toxicology, Pavia Poison Centre, National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.
Paola RossiDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Maria Grazia BottoneDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
University of Pavia · ITIstituti Clinici Scientifici Maugeri · ITNational Center for Oncological Hadrontherapy · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is the most common tumor of the central nervous system. Current therapies, often associated with severe side effects, are inefficacious to contrast the GBM relapsing forms. In trying to overcome these drawbacks, (

Indexed as

carbon ions irradiation effectsglioblastomaglioblastoma (GBM)hadrontherapyin vitroplatinum(IV) chemotherapeuticstumor resistance

Identifiers

PMID33828444
PMCPMC8019820
OpenAlexW3139095076

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.