Evidence map›Paper›PMID 33830019›Full record

ArticleeLife2021

Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics.

Juana Serrano-Lopez, Shailaja Hegde, Sachin Kumar, Josefina Serrano, Jing Fang, Ashley M Wellendorf, Paul A Roche, Yamileth Rangel, Leolene J Carrington, Hartmut Geiger and 6 more

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 5 countries.

Juana Serrano-Lopez *Divisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.
Shailaja Hegde *Divisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.
Sachin KumarDivisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.
Josefina SerranoHematology Department, Reina Sofía University Hospital/Maimonides Biomedical Research Institute of Córdoba (IMIBIC)/University of Córdoba, Córdoba, Spain.
Jing FangDivisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.
Ashley M WellendorfDivisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.
Paul A RocheCenter for Cancer Research, National Cancer Institute, Bethesda, United States.
Yamileth RangelHematology Department, Reina Sofía University Hospital/Maimonides Biomedical Research Institute of Córdoba (IMIBIC)/University of Córdoba, Córdoba, Spain.
Leolene J CarringtonUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, United States.ORCID 0000-0002-7352-3270
Hartmut GeigerDivisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.ORCID 0000-0002-5794-5430
H Leighton GrimesImmunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.
Sanjiv LutherCenter for Immunity and Infection, Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Ivan MaillardUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
Joaquin Sanchez-GarciaHematology Department, Reina Sofía University Hospital/Maimonides Biomedical Research Institute of Córdoba (IMIBIC)/University of Córdoba, Córdoba, Spain.
Daniel T StarczynowskiDivisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.
Jose A CancelasDivisions of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.ORCID 0000-0002-1291-7233
Cincinnati Children's Hospital Medical Center · USInstituto Maimónides de Investigación Biomédica de Córdoba · ESUniversity of Pennsylvania · USInstitute of Infection and Immunity · CANational Institutes of Health · US

Funding

HEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1M
Notch Signaling in AlloimmunityR01AI091627 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI PEAR, WARREN S · 2011 to 2025
$6.0M
Decoding innate immune signaling in normal and myelodysplastic hematopoiesisR35HL135787 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI STARCZYNOWSKI, DANIEL · 2017 to 2022
$4.6M
Cincinnati Center for Excellence in Molecular HematologyP30DK090971 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ZHENG, YI · 2010 to 2015
$4.0M
Regulation of Exocytosis from Immune CellsZIABC011035 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ROCHE, PAUL · 2009 to 2025
$3.0M
Targeting IRAK1/4 in Myelodysplastic SyndromesR01DK113639 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI STARCZYNOWSKI, DANIEL · 2017 to 2020
$1.9M
Mitochondria mediated intercellular metabolic coupling in bone marrow regenerationR01DK124115 · NIDDK · DANA-FARBER CANCER INST · PI Jose A. Cancelas · 2020 to 2026
$1.9M
G-CSF in Human Severe Congenital NeutropeniaR01GM110628 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI CANCELAS, JOSE A., LUTZKO, CAROLYN M · 2015 to 2018
$1.2M
NHLBI NIH HHS R35 HL135787NHLBI NIH HHS T32 HL007439NIAID NIH HHS R01 AI091627NIDDK NIH HHS P30 DK090971NIDDK NIH HHS R01 DK113639NIDDK NIH HHS R01 DK124115NIGMS NIH HHS R01 GM110628
6 · The paper itself

Abstract

Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emergent activation of a previously unrecognized system of rapid migration of granulocyte-macrophage progenitors and committed macrophage-dendritic progenitors, but not other progenitors or stem cells, from bone marrow (BM) to regional lymphatic capillaries. The progenitor traffic to the systemic lymphatic circulation is mediated by Ccl19/Ccr7 and is NF-κB independent, Traf6/IκB-kinase/SNAP23 activation dependent, and is responsible for the secretion of pre-stored Ccl19 by a subpopulation of CD205

Indexed as

Cell MovementAdolescentAdultAgedAged, 80 and overAnimalsBone MarrowCell LineageCells, CulturedChildChild, PreschoolDisease Models, AnimalFemaleGranulocyte-Macrophage Progenitor CellsHumansInflammationInflammation Mediatorsbone marrowcirculationendotoxemiahumanimmunologyinflammationlymphaticsmedicinemousemyeloid progenitors

Identifiers

PMID33830019
PMCPMC8137144
OpenAlexW3143332846

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.