ArticleArthritis research & therapy2021
Periostin loss-of-function protects mice from post-traumatic and age-related osteoarthritis.
Article in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- Periostin in joint physiology and pathology: multiple roles from mechanisms to clinical perspectives.Histochemistry and cell biology · 2026Review
- A novel infrapatellar fat pad preservation technique in anterior cruciate ligament reconstruction reduces postoperative pain and cartilage damage: a retrospective study.Journal of orthopaedic surgery and research · 2025Article
- A multi-tissue human knee single-cell atlas identifies that osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages.Communications biology · 2025Article
- Proteomics Reveals Increased Periostin in Synovial Fluid From Canine and Human Anterior Cruciate Ligament Injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- A review of periostin in orthopedics.Osteoarthritis and cartilage open · 2025Review
- Development of animal model for anterior open bite and mechanism of temporomandibular joint morphological change: an implication for MAC surgery.BMC oral health · 2025Article
- Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration.Journal of neuroinflammation · 2025Article
- Advances in the Regulation of Periostin for Osteoarthritic Cartilage Repair Applications.Biomolecules · 2024Article
- Loss of periostin function impairs ligament fibroblast activity and facilitates ROS-mediated cellular senescence.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Article
- PDK4 inhibits osteoarthritis progression by activating the PPAR pathway.Journal of orthopaedic surgery and research · 2024Article
- Single-cell profiling uncovers synovial fibroblast subpopulations associated with chondrocyte injury in osteoarthritis.Frontiers in endocrinology · 2024Article
- Development of a top-down MS assay for specific identification of human periostin isoforms.Frontiers in molecular biosciences · 2024Article
- Impaired fracture healing is associated with callus chondro-osseous junction abnormalities in periostin-null and osteopontin-null mice.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury.Science advances · 2023Article
- IL-6 induces periostin production in human ACL remnants: a possible mechanism causing post-traumatic osteoarthritis.Journal of orthopaedic surgery and research · 2023Article
- Periostin regulation and cartilage degradation early after anterior cruciate ligament reconstruction.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- Transcriptomic changes in porcine articular cartilage one year following disruption of the anterior cruciate ligament.PloS one · 2023Article
- Serum periostin level is not sufficient to serve as a clinically applicable biomarker of osteoarthritis.BMC musculoskeletal disorders · 2022Article
- Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundElevated levels of periostin (Postn) in the cartilage and bone are associated with osteoarthritis (OA). However, it remains unknown whether Postn loss-of-function can delay or prevent the development of OA. In this study, we sought to better understand the role of Postn in OA development and assessed the functional impact of Postn deficiency on post-traumatic and age-related OA in mice.
methodsThe effects of Postn deficiency were studied in two murine experimental OA models using Postn
resultsPostn
conclusionsPostn deficiency protects against DMM-induced post-traumatic and age-related spontaneous OA. RNA-seq findings warrant further investigations to better understand the mechanistic role of Postn and its potential as a therapeutic target in OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.