ArticleDiabetes care2021
Efficacy and Safety of Mulberry Twig Alkaloids Tablet for the Treatment of Type 2 Diabetes: A Multicenter, Randomized, Double-Blind, Double-Dummy, and Parallel Controlled Clinical Trial.
Open access · bronzeAbstract readEquivalence TrialMulticenter Study
In one paragraph
Article in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
7.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Integrative Evidence on Mulberry Extract for Modulating Metabolic Risk Factors Associated with Vascular Dementia.International journal of molecular sciences · 2025Pooled it
- Mulberry twig alkaloids for type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Evidence of traditional Chinese medicine for treating type 2 diabetes mellitus: from molecular mechanisms to clinical efficacy.Pharmaceutical biology · 2024Pooled it
- Preclinical Evidence of Mulberry Leaf Polysaccharides on Diabetic Kidney Disease: a Systematic Review and Meta-Analysis.Planta medica · 2024Pooled it
- Effects of mulberry twig alkaloids and canagliflozin in inadequately controlled type 2 diabetes: a randomized controlled study based on flash glucose monitoring.Scientific reports · 2026Trial
- Mulberry Twig Alkaloids Combined With Insulin Infusion: Effects on Blood Glucose Variability in Type 2 Diabetes.Medical science monitor : international medical journal of experimental and clinical research · 2026Trial
- Effects of mulberry twig alkaloids(Sangzhi alkaloids) and metformin on blood glucose fluctuations in combination with premixed insulin-treated patients with type 2 diabetes.Frontiers in endocrinology · 2023Trial
- Efficacy and Safety of Mulberry Twig Alkaloids Tablet for Treatment of Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Study.Chinese journal of integrative medicine · 2022Trial
- Mulberry Leaf-Derived Bioactive Constituents on Diabetes: Structure, Extraction, Quality Analysis, and Hypoglycemic Mechanisms.Molecules (Basel, Switzerland) · 2026Review
- Recent advances and ongoing challenges in diabetes prevention and control in China.Innovation (Cambridge (Mass.)) · 2026Review
- Application of Traditional Chinese Medicines in Diabetes Mellitus: From Pathogenesis to Clinical Practice.Current pharmaceutical biotechnology · 2026Review
- "Golden cicada-escape" style colon-targeted pellets for ulcerative colitis by balancing oxidative stress and repairing colonic barrier.Materials today. Bio · 2025Article
- Network pharmacology-based investigation of potential targets of mulberry twig acting on polycystic ovary syndrome.Medicine · 2025Article
- An HDG11-mediated transcriptional network regulates 1-deoxynojirimycin biosynthesis in mulberry.Plant physiology · 2025Article
- Article
- Colon-Targeted Mucoadhesive PLGA Microspheres Loaded withMolecules (Basel, Switzerland) · 2025Article
- Ramulus mori (Sangzhi) alkaloids improve intestinal oxidative damage and inflammation in DHEA-induced polycystic ovary syndrome rats via gut microbiota and metabolite modulation.Frontiers in pharmacology · 2025Article
- The role of Nrf2 signaling pathway in diabetic cardiomyopathy: from pathogenesis to traditional Chinese medicine interventions.Frontiers in cardiovascular medicine · 2025Review
- Cremastrae Pseudobulbus Pleiones Pseudobulbus (CPPP) Against Non-Small-Cell Lung Cancer: Elucidating Effective Ingredients and Mechanism of Action.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 18 institutions in 1 country.
Ling QuDepartment of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID 0000-0002-5504-7223
Xiaochun LiangDepartment of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China xcliang@vip.sina.com gq_tian@126.com.
Guoqing TianDepartment of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China xcliang@vip.sina.com gq_tian@126.com.ORCID 0000-0003-1262-2723
Gaili ZhangDepartment of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Qunli WuDepartment of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xiumei HuangDepartment of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yazhong CuiDepartment of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yuling LiuInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhufang ShenInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Changqing XiaoDepartment of Endocrinology and Metabolism, The First Affiliated Hospital, Guangxi Medical University, Guangxi, China.
Yingfen QinDepartment of Endocrinology, The First Affiliated Hospital, Guangxi Medical University, Guangxi, China.ORCID 0000-0002-8456-1678
Heng MiaoDepartment of Endocrinology, The Second Affiliated Hospital, Nan Jing Medical University, Jiangsu, China.
Yongyan ZhangDepartment of Endocrinology, Shengjing Hospital of China Medical University, Liaoning, China.
Ziling LiDepartment of Endocrinology, Inner Mongolia Baogang Hospital, Baotou, Inner Mongolia Autonomous Region, China.
Shandong YeDepartment of Endocrinology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, USTC, Hefei, Anhui, China.
Xuezhi ZhangTraditional Chinese Medicine and Integrative Medicine Department, Peking University First Hospital, Beijing, China.
Jing YangDepartment of Endocrinology, The First Affiliated Hospital, Shanxi Medical University, Shanxi, China.
Guiwen CaoDepartment of Endocrinology, The Fourth Affiliated Hospital, Jilin University, Jilin, China.
Yi LiDepartment of Traditional Chinese Medicine, Beijing Hospital, Beijing, China.
Gangyi YangDepartment of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Ji HuDepartment of Endocrinology, The Second Affiliated Hospital, Suzhou University, Jiangsu, China.
Xiaoyue WangDepartment of Endocrinology, The First People's Hospital of Yueyang, Hunan, China.
Zhengfang LiDepartment of Endocrinology, The Second Affiliated Hospital, Kunming Medical University, Yunnan, China.
Yukun LiDepartment of Endocrinology, The Third Affiliated Hospital, Hebei Medical University, Hebei, China.ORCID 0000-0002-7484-9803
Xiuzhen ZhangDepartment of Endocrinology, Tongji Hospital, Tongji University, Shanghai, China.
Guangde ZhangDepartment of Endocrinology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China.
Li ChenDepartment of Endocrinology, Qilu Hospital, Shandong University, Shandong, China.ORCID 0000-0001-7670-8062
Wenjin HuaDepartment of Endocrinology, The Third People's Hospital of Wuxi, Jiangsu, China.
Ming YuDepartment of Endocrinology, Central Hospital of Putuo District, Shanghai, China.
Chunyan LuDepartment of Endocrinology, West China Hospital, Sichuan University, Sichuan, China.
Xiaomei ZhangDepartment of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Anhui, China.
Hong JiangDepartment of Endocrinology, The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNTongji University · CNGuangxi Medical University · CNHebei Medical University · CNKunming Medical University · CNAffiliated Hospital of Liaoning University of Traditional Chinese Medicine · CNCentral Hospital of Putuo District · CNChina Medical University · CNDalian Medical University · CNJilin University · CNQilu Hospital of Shandong University · CNSecond Affiliated Hospital of Nanjing Medical University · CNShanxi Medical University · CNSichuan University · CNSoochow University · CNUniversity of Science and Technology of China · CNWuxi Third People's Hospital · CNYueyang Second People's Hospital · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate the efficacy and safety of mulberry twig alkaloids (Sangzhi alkaloids [SZ-A]) in the treatment of type 2 diabetes (T2D). RESEARCH DESIGN AND
methodsThis was a multicenter, randomized, double-blind, double-dummy, and parallel controlled noninferiority clinical trial that was conducted for 24 weeks. A total of 600 patients were randomly allocated to the SZ-A group (
resultsAfter treatment for 24 weeks, the change in HbA
conclusionsSZ-A exhibited equivalent hypoglycemic effects to acarbose in patients with T2D. Nevertheless, the incidence of TAEs and GDs was lower following SZ-A treatment than acarbose treatment, suggesting good safety.
Indexed as
AlkaloidsDiabetes Mellitus, Type 2MorusBlood GlucoseDouble-Blind MethodDrug Therapy, CombinationGlycated HemoglobinHumansHypoglycemic AgentsTabletsTreatment OutcomeAlkaloidsBlood GlucoseGlycated HemoglobinHypoglycemic AgentsTablets
Identifiers
What Socratic holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.