Evidence map›Paper›PMID 33834402›Full record

ArticleAdvances in experimental medicine and biology2021

Genetic Architecture of Depression: Where Do We Stand Now?

Pinar Unal-Aydin, Orkun Aydin, Ayla Arslan

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Navigating the Intersection of Technology and Depression Precision Medicine.Advances in experimental medicine and biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pinar Unal-AydinPsychology Program, International University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Orkun AydinPsychology Program, International University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Ayla ArslanSchool of Advanced Studies, University of Tyumen, Tyumen, Russia. a.arslan@utmn.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The research of depression genetics has been occupied by historical candidate genes which were tested by candidate gene association studies. However, these studies were mostly not replicable. Thus, genetics of depression have remained elusive for a long time. As research moves from candidate gene association studies to GWAS, the hypothesis-free non-candidate gene association studies in genome-wide level, this trend will likely change. Despite the fact that the earlier GWAS of depression were not successful, the recent GWAS suggest robust findings for depression genetics. These altogether will catalyze a new wave of multidisciplinary research to pin down the neurobiology of depression.

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyDepressionHumansPolymorphism, Single NucleotideAssociation studiesCandidate genesDepressionDepression geneticsGeneticsGenome-wide association studyGWAS

Identifiers

PMID33834402

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.