Evidence map›Paper›PMID 33834670›Full record

ArticleHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology2021

[Expression of cyclophilin A in oral squamous cell carcinoma and its effect on cell proliferation and invasion].

Xiao-Yang Xia, Fei Fang, Yan Liu, Chao Che, Jin-Juan Ke, Sheng-Jun Jiang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiao-Yang XiaDept. of Stomatology, Hubei Integrated Traditional Chinese and Western Medicine Hospital, Wuhan 430015, China.
Fei FangDept. of Stomatology, Hubei Integrated Traditional Chinese and Western Medicine Hospital, Wuhan 430015, China.
Yan LiuDept. of Stomatology, Hubei Integrated Traditional Chinese and Western Medicine Hospital, Wuhan 430015, China.
Chao CheDept. of Stomatology, Hubei Integrated Traditional Chinese and Western Medicine Hospital, Wuhan 430015, China.
Jin-Juan KeDept. of Stomatology, Hubei Integrated Traditional Chinese and Western Medicine Hospital, Wuhan 430015, China.
Sheng-Jun JiangDept. of Stomatology, Wuhan University People,s Hospital, Wuhan 430060, China.
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the expression of cyclophilin A (CyPA) in oral squamous cell carcinoma (OSCC) and explore the effect of downregulating the expression of CyPA gene on the proliferation and invasion of SCC-25 cells.

methodsA total of 77 cases of patients with OSCC were selected. The expression levels of CyPA proteins in OSCC and adjacent normal tissues were evaluated. SCC-25 cells were cultured and divided into the CyPA interference sequence group, negative control group, and blank group. The expression levels of CyPA mRNA and protein in cells were detected by using real-time fluorescent quantitative polymerase chain reaction and Western blot, respectively. Cell proliferation was detected by using methyl thiazolyl tetrazolium and plate colony formation assays. Cell invasion was detected by using Transwell assay.

resultsThe positive expression rate of CyPA protein in OSCC tissues was 76.62%, which was higher than that in adjacent tissues (

conclusionsThe CyPA protein is highly expressed in OSCC tissues, and the downregulation of CyPA gene expression in SCC-25 cells can reduce cell proliferation and inhibit cell invasion.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsCell Line, TumorCell MovementCell ProliferationCyclophilin AGene Expression Regulation, NeoplasticHumansSquamous Cell Carcinoma of Head and NeckCyclophilin Acell proliferationcyclophilin Ainvasivenessoral squamous cell carcinoma

Identifiers

PMID33834670
PMCPMC8055773
OpenAlexW3142248610

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.