Evidence map›Paper›PMID 33835753›Full record

ArticleJournal of clinical neurology (Seoul, Korea)2021

Evaluation of Reproducibility of Brain Volumetry between Commercial Software, Inbrain and Established Research Purpose Method, FreeSurfer.

Jungbin Lee, Ji Young Lee, Se Won Oh, Mi Sun Chung, Ji Eun Park, Yeonsil Moon, Hong Jun Jeon, Won Jin Moon

Open access · diamondAbstract read
In one paragraph

Article in Journal of clinical neurology (Seoul, Korea), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Current Clinical Applications of Structural MRI in Neurological Disorders.Journal of clinical neurology (Seoul, Korea) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Jungbin LeeDepartment of Radiology, Soonchunghyang University Bucheon Hospital, Bucheon, Korea.ORCID https://orcid.org/0000-0002-6240-8277
Ji Young LeeDepartment of Radiology, Hanyang University Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0003-1181-8070
Se Won OhDepartment of Radiology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.ORCID https://orcid.org/0000-0003-1336-4498
Mi Sun ChungDepartment of Radiology, Chung-Ang University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-1141-9555
Ji Eun ParkDepartment of Radiology, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-4419-4682
Yeonsil MoonDepartment of Neurology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7770-4127
Hong Jun JeonDepartment of Psychiatry, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-0260-0494
Won Jin MoonDepartment of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. mdmoonwj@kuh.ac.kr.ORCID https://orcid.org/0000-0002-8925-7376
Konkuk University Medical Center · KRHanyang University Medical Center · KRAsan Medical Center · KRChung-Ang University Hospital · KRSoonchunhyang University · KR

Funding

Korea Health Industry Development Institute HI18C1038
6 · The paper itself

Abstract

background and purposeWe aimed to determine the intermethod reproducibility between the commercial software Inbrain (MIDAS IT) and the established research-purpose method FreeSurfer, as well as the effect of MRI resolution and the pathological condition of subjects on their intermethod reproducibility.

methodsThis study included 45 healthy volunteers and 85 patients with mild cognitive impairment (MCI). In 43 of the 85 patients with MCI, three-dimensional, T1-weighted MRI data were obtained at an in-plane resolution of 1.2 mm. The data of the remaining 42 patients with MCI and the healthy volunteers were obtained at an in-plane resolution of 1.0 mm. The within-subject coefficient of variation (CoV), intraclass correlation coefficient (ICC), and effect size were calculated, and means were compared using paired

resultsOverall the two methods showed excellent reproducibility across all regions of the brain (CoV=0.5-3.9, ICC=0.93 to >0.99). In the subgroup of healthy volunteers, the intermethod reliability was only good in some regions (frontal, temporal, cingulate, and insular). The intermethod reproducibility was better in the 1.0-mm group than the 1.2-mm group in all regions other than the nucleus accumbens.

conclusionsInbrain and FreeSurfer showed good-to-excellent intermethod reproducibility for volumetric measurements. Nevertheless, some noticeable differences were found based on subject condition, image resolution, and brain region.

Indexed as

brain, volumetrymagnetic resonance imagingmild cognitive impairmentreproducibility of results

Identifiers

PMID33835753
PMCPMC8053534
OpenAlexW3142281186

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.