Evidence map›Paper›PMID 33837264›Full record

ArticleScientific reports2021

Characterization of clostridium botulinum neurotoxin serotype A (BoNT/A) and fibroblast growth factor receptor interactions using novel receptor dimerization assay.

Nicholas G James, Shiazah Malik, Bethany J Sanstrum, Catherine Rhéaume, Ron S Broide, David M Jameson, Amy Brideau-Andersen, Birgitte S Jacky

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
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  9. OnabotulinumtoxinA effects on trigeminal nociceptors.Cephalalgia : an international journal of headache · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Nicholas G JamesDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St., BSB 222, Honolulu, HI, 96813, USA.
Shiazah MalikNeurotoxin Research Program, Department of Biological Sciences, Allergan (an AbbVie Company) R&D, 2525 Dupont Dr., RD3-3B, Irvine, CA, 92612, USA.
Bethany J SanstrumDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St., BSB 222, Honolulu, HI, 96813, USA.
Catherine RhéaumeNeurotoxin Research Program, Department of Biological Sciences, Allergan (an AbbVie Company) R&D, 2525 Dupont Dr., RD3-3B, Irvine, CA, 92612, USA.
Ron S BroideNeurotoxin Research Program, Department of Biological Sciences, Allergan (an AbbVie Company) R&D, 2525 Dupont Dr., RD3-3B, Irvine, CA, 92612, USA.
David M JamesonDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St., BSB 222, Honolulu, HI, 96813, USA.
Amy Brideau-AndersenNeurotoxin Research Program, Department of Biological Sciences, Allergan (an AbbVie Company) R&D, 2525 Dupont Dr., RD3-3B, Irvine, CA, 92612, USA.
Birgitte S JackyNeurotoxin Research Program, Department of Biological Sciences, Allergan (an AbbVie Company) R&D, 2525 Dupont Dr., RD3-3B, Irvine, CA, 92612, USA. birgitte.jacky@allergan.com.
Allergan (Ireland) · IEUniversity of Hawaiʻi at Mānoa · USAllergan (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clostridium botulinum neurotoxin serotype A (BoNT/A) is a potent neurotoxin that serves as an effective therapeutic for several neuromuscular disorders via induction of temporary muscular paralysis. Specific binding and internalization of BoNT/A into neuronal cells is mediated by its binding domain (H

Indexed as

SerogroupAnimalsBinding SitesBotulinum Toxins, Type ACell MembraneClostridium botulinumDimerizationErbB ReceptorsGangliosidesMembrane GlycoproteinsNerve Tissue ProteinsNeuronsNeurotoxinsPC12 CellsProtein BindingProtein DomainsBotulinum Toxins, Type AEgfr protein, ratErbB ReceptorsGangliosidesMembrane GlycoproteinsNerve Tissue ProteinsNeurotoxinsReceptors, Cell SurfaceReceptors, Fibroblast Growth FactorSv2a protein, rattrisialoganglioside GT1

Identifiers

PMID33837264
PMCPMC8035261
OpenAlexW3147531946

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.