SynthesisEuropean journal of clinical nutrition2021
Preconceptional maternal weight loss and hypertensive disorders in pregnancy: a systematic review and meta-analysis.
Synthesis in European journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- The effect of methods used in the management of maternal obesity on pregnancy and birth outcomes: a systematic review with meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Further development and (cost-)effectiveness of the Smarter Pregnancy lifestyle program tailored for pregnant women with obesity (HYGEIA trial).BMC pregnancy and childbirth · 2026Trial
- Hypertensive disorders of pregnancy and women's health throughout the life course: an update review 2025-2026.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Pregnancy after bariatric surgery: persistent obesity and longer time to conception influences peripartum outcomes more than the type of operation.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2026Article
- Weight management in women of reproductive age.Obesity and endocrinology · 2026Review
- Periconceptional GLP-1 receptor agonist exposure and obstetric outcomes: a Danish nationwide cohort study.Human reproduction open · 2026Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- The effect of maternal and fetal weight on the risk of emergency cesarean section in nulliparous women.Medicine · 2025Observational
- The dual burden of obesity: decoding metabolism and female reproductive endocrinology.Frontiers in physiology · 2025Review
- Conceiving during the first postoperative year after bariatric surgery: a retrospective study of pregnancy outcomes.BMC pregnancy and childbirth · 2024Article
- Pregnancy as an Early Cardiovascular Moment: Peripartum Cardiovascular Health.Circulation research · 2023Review
- Chronic Hypertension in Pregnancy: A Lens Into Cardiovascular Disease Risk and Prevention.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Article
- Intersection of Acquired and Congenital Cardiovascular Disorders in Pregnancy.JACC. Advances · 2022Article
- Pregnancy Complications in Women with Weight Loss Surgery Compared to a Non-Surgical Population of Women with Obesity.Obesity surgery · 2022Article
- The etiology of preeclampsia.American journal of obstetrics and gynecology · 2022Review
- Obesity in pregnant women: maternal, fetal, and transgenerational consequences.European journal of clinical nutrition · 2021Article
- Prepregnancy Overweight and Obesity in Kuwait Birth Cohort Study.Public health nursing (Boston, Mass.)Review
- A Women's health perspective on managing obesity.Progress in cardiovascular diseasesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertensive disorders of pregnancy (HDP), including pregnancy-induced hypertension (PIH), Preeclampsia (PE), Hemolysis Elevated Liver enzymes and Low Platelets (HELLP) and chronic hypertension, are leading causes of maternal and perinatal morbidity and mortality. Although the pathophysiology of HDP is complex, preconceptional weight reduction in obese women might reduce these complications. We conducted a systematic review and meta-analysis to investigate the effectiveness of preconceptional weight loss by lifestyle intervention or bariatric surgery in overweight and obese women and the reduction of the risk of HDP. METHODS AND
resultsDatabases are searched until September 2019 resulting in 2547 articles: 110 full-text analysis and 29 detailed analysis. Reduced risks were shown for HDP in seven articles (n = 4381) of weight loss after lifestyle intervention or bariatric surgery (OR range 0.10-0.64), for PIH in four articles (n = 46,976) (OR range 0.14-0.79), and for PE in seven articles (n = 169,734) (OR range 0.14-0.84). The stratified analysis of weight loss after lifestyle intervention and bariatric surgery shows comparable results. The meta-analysis of 20 studies of the effectiveness of lifestyle intervention and bariatric surgery revealed reduced risks of HDP (OR 0.45 (95% CI 0.32-0.63)), PIH (OR 0.61 (95%CI 0.44-0.85)) and PE (OR 0.67 (95%CI 0.51-0.88)).
conclusionsPreconceptional weight loss after lifestyle intervention or bariatric surgery is effective in reducing risks of HDP, PIH and PE, and emphasizes the need to optimize weight in overweight and obese women with a child wish. More research is recommended to investigate short-term and long-term beneficial and harmful side-effects of these interventions on maternal and offspring health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.