Evidence map›Paper›PMID 33839151›Full record

ArticleThe Journal of biological chemistry

Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N

Pratibha P Ghodke, Jyotirling R Mali, Amritraj Patra, Carmelo J Rizzo, F Peter Guengerich, Martin Egli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Mechanisms of DNA repair and mutagenesis induced by acetaldehyde, acrolein, aristolochic acids, and vinyl chloride.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2025
    Review
  4. Replication Bypass of theBiochemistry · 2024
    Article
  5. Formation of the mutagenic DNA lesion 1,NGenes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023
    Article
  6. Review
  7. Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021
    Review
  8. Beyond the Lesion: Back to High Fidelity DNA Synthesis.Frontiers in molecular biosciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pratibha P GhodkeDepartment of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Jyotirling R MaliDepartment of Chemistry, College of Arts and Science, Vanderbilt University, Nashville, Tennessee, USA.
Amritraj PatraDepartment of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Carmelo J RizzoDepartment of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA; Department of Chemistry, College of Arts and Science, Vanderbilt University, Nashville, Tennessee, USA; Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
F Peter GuengerichDepartment of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA; Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
Martin EgliDepartment of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA; Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA. Electronic address: martin.egli@vanderbilt.edu.
Vanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Synthetic Approaches to Carcinogen-Linked OligonucleotidesP01CA160032 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2012 to 2022
$14.0M
BIOACTIVATION OF HALOGENATED HYDROCARBONSR01ES010546 · NIEHS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2001 to 2020
$8.1M
Mechanisms of Copying of Carcinogen-damaged DNA and RNA by Translesion PolymerasesR01ES026955 · NIEHS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2017 to 2021
$1.8M
NCI NIH HHS P01 CA160032NCI NIH HHS P30 CA068485NIEHS NIH HHS R01 ES010546NIEHS NIH HHS R01 ES026955
6 · The paper itself

Abstract

Etheno (ε)-adducts, e.g., 1,N

Indexed as

Chromatography, LiquidCrystallography, X-RayDeoxyguanosineDNA AdductsDNA-Directed DNA PolymeraseHumansTandem Mass Spectrometry1,N(2)-ethenodeoxyguanosineDeoxyguanosineDNA AdductsDNA-Directed DNA PolymeraseDNA damageDNA polymeraseDNA–protein interactionDNA replicationetheno DNA adductsmass spectrometrytranslesion synthesisX-ray crystallography

Identifiers

PMID33839151
PMCPMC8121704
OpenAlexW3152658475

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.