Evidence map›Paper›PMID 33839774›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022

Associations Between 20-Year Lipid Variability Throughout Young Adulthood and Midlife Cognitive Function and Brain Integrity.

Adina Zeki Al Hazzouri, Michelle R Caunca, Neal Jawadekar, Leslie Grasset, Tali Elfassy, Michelle C Odden, Chenkai Wu, Martine Elbejjani, Lenore Launer, Kristine Yaffe

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PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 4 countries.

Adina Zeki Al HazzouriDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
Michelle R CauncaDepartments of Neurology and Public Health Sciences, Miller School of Medicine, University of Miami, Florida, USA.ORCID 0000-0002-5177-9048
Neal JawadekarDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.ORCID 0000-0002-0217-6398
Leslie GrassetUniversité de Bordeaux, INSERM, Bordeaux Population Health Research Center, Team VINTAGE UMR1219, France.
Tali ElfassyDivision of Epidemiology, Department of Public Health Sciences, University of Miami, Florida, USA.ORCID 0000-0002-7528-7988
Michelle C OddenDepartment of Health Research and Policy, Stanford University, Palo Alto, California, USA.ORCID 0000-0002-5974-3648
Chenkai WuDepartment of Global Health, Duke Kunshan University, Suzhou,China.ORCID 0000-0002-2256-0653
Martine ElbejjaniClinical Research Institute, Department of Internal Medicine, American University of Beirut, Lebanon.
Lenore LaunerLaboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Kristine YaffeDepartments of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California San Francisco, USA.
Columbia University · USUniversity of Miami · USAmerican University of Beirut · LBDuke Kunshan University · CNNational Institutes of Health · USStanford University · USUniversité de Bordeaux · FRUniversity of California, San Francisco · US

Funding

ALZHEIMER RESEARCH PROJECT: Brain aging and cardiovascular risk factors and diseaseZIAAG007480 · NATIONAL INSTITUTE ON AGING · 2025 to 2025
$111k
NHLBI NIH HHS AG0005NHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNIA NIH HHS K01 AG047273NIA NIH HHS R01 AG063887NIA NIH HHS R35 AG071916NIH HHSNINDS NIH HHS F30 NS103462NINDS NIH HHS F30NS103462
6 · The paper itself

Abstract

backgroundLittle is known about long-term lipid variability in young adulthood in relation to cognitive function and brain integrity in midlife.

methodWe studied 3 328 adults from the Coronary Artery Risk Development in Young Adults. We defined low- and high-density lipoprotein (LDL and HDL) variability as the intraindividual standard deviation of lipid measurements over 20 years of young adulthood (1985-2005). Cognitive tests were administered in 2010. Brain scans were performed in 2010 on 714 participants. To facilitate comparison, cognitive tests and brain metrics were z-scored.

resultsMean age at baseline was 25.4 years. Higher 20-year LDL variability was associated with worse verbal memory in midlife (β = -0.25, 95% CI: -0.42, -0.08), adjusted for important covariates. Higher 20-year HDL variability was associated with worse processing speed in midlife (β = -0.80, 95% CI: -1.18, -0.41) and brain integrity, for example, smaller total brain volume (β = -0.58, 95% CI: -0.82, -0.34) and worse total brain fractional anisotropy (β = -1.13, 95% CI: -1.87, -0.39).

conclusionsHigher long-term lipid variability in adulthood was associated with worse cognition and brain integrity in midlife, in a relatively young cohort.

Indexed as

BrainCognitionAdultHumansLipidsMemoryNeuropsychological TestsRisk FactorsYoung AdultLipidsBrainCognitionEpidemiologyHomeostasisLipid

Identifiers

PMID33839774
PMCPMC8751805
OpenAlexW3153439976

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.