Evidence map›Paper›PMID 33839788›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2022

Effect of Aerobic or Resistance Exercise, or Both, on Intermuscular and Visceral Fat and Physical and Metabolic Function in Older Adults With Obesity While Dieting.

Debra L Waters, Lina Aguirre, Burke Gurney, David R Sinacore, Kenneth Fowler, Giulia Gregori, Reina Armamento-Villareal, Clifford Qualls, Dennis T Villareal

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06004427 (Investigation of the Effectiveness of Resistance Exercise Program Given With Diet in Obese Individuals.), which is not on this map. Cited by 50 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 5 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06004427 nacompletednot on this mapstarted 2023, after this paper: background citation

Investigation of the Effectiveness of Resistance Exercise Program Given With Diet in Obese Individuals.

TypeinterventionalSponsorUskudar UniversityRan2023 to 2023Enrolled50ConditionsObesityArmsDiet program, Exercise training protocols
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 5 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Debra L WatersDepartment of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, USA.
Lina AguirreDepartment of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, USA.
Burke GurneyDivision of Physical Therapy, School of Medicine, University of New Mexico, Albuquerque, USA.
David R SinacoreDepartment of Physical Therapy, High Point University, North Carolina, USA.
Kenneth FowlerNew Mexico Veterans Affairs Health Care System, Albuquerque, USA.
Giulia GregoriDivision of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas, USA.
Reina Armamento-VillarealDivision of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas, USA.
Clifford QuallsDepartment of Mathematics and Statistics, School of Medicine, University of New Mexico, Albuquerque, USA.
Dennis T VillarealDivision of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-1365-7960
University of New Mexico · USMichael E. DeBakey VA Medical Center · USHigh Point University · USNew Mexico VA Health Care System · US

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · 2022 to 2025
$5.6M
NCATS NIH HHS UL1 TR000041NIA NIH HHS R01 AG031176NIDDK NIH HHS P30 DK020579
6 · The paper itself

Abstract

backgroundObesity exacerbates age-related effects on body composition and physical and metabolic function. Which exercise mode is most effective in mitigating these deleterious changes in dieting older adults with obesity is unknown.

methodsIn a randomized controlled trial, we performed a head-to-head comparison of aerobic (AEX), resistance (REX), or combination (COMB) exercise during matched ~10% weight loss in 160 obese older adults. Prespecified analyses compared 6-month changes in intermuscular adipose tissue (IMAT) and visceral adipose tissue (VAT) assessed using MRI, insulin sensitivity index (ISI) by oral glucose tolerance test, physical function using Modified Physical Performance Test (PPT), VO2peak, gait speed, and knee strength by dynamometry.

resultsIMAT and VAT decreased more in COMB than AEX and REX groups (IMAT; -41% vs -28% and -23% and VAT: -36% vs -19% and -21%; p = .003 to .01); IMAT and VAT decreased in all groups more than control (between-group p < .001). ISI increased more in COMB than AEX and REX groups (86% vs 50% and 39%; p = .005 to .03). PPT improved more in COMB than AEX and REX groups, while VO2peak improved more in COMB and AEX than REX group (all p < .05). Knee strength improved more in COMB and REX than AEX group (all p < .05). Changes in IMAT and VAT correlated with PPT (r = -0.28 and -0.39), VO2peak (r = -0.49 and -0.52), gait speed (r = -0.25 and -0.36), and ISI (r = -0.49 and -0.52; all p < .05).

conclusionsWeight loss plus combination aerobic and resistance exercise was most effective in improving ectopic fat deposition and physical and metabolic function in older adults with obesity.

Indexed as

Intra-Abdominal FatResistance TrainingAgedExerciseHumansObesityWeight LossClinical trialsExerciseFunctional performanceObesity

Identifiers

PMID33839788
PMCPMC8751785
OpenAlexW3154093594

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.