SynthesisFrontiers in neuroscience2021
New Insight of Circular RNAs' Roles in Central Nervous System Post-Traumatic Injury.
Synthesis in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- MiR499-5P loaded MSC derived exosomes affect oxidative stress and inflammatory response after spinal cord injury by targeting genes.Journal of orthopaedic surgery and research · 2025Article
- CircKat6b Mediates the Antidepressant Effect of Esketamine by Regulating Astrocyte Function.Molecular neurobiology · 2025Article
- NcRNAs: a potential treatment for spinal cord injury.Frontiers in cellular neuroscience · 2025Review
- The roles of circular RNAs in nerve injury and repair.Frontiers in molecular neuroscience · 2024Review
- Identification of Novel Circular RNA Targets in Key Penumbra Region of Rats After Cerebral Ischemia-Reperfusion Injury.Journal of molecular neuroscience : MN · 2023Article
- Circular RNA hsa_circ_0000690 as a potential biomarker for diagnosis and prognosis of intracranial aneurysm: Closely relating to the volume of hemorrhage.Brain and behavior · 2023Article
- Circular RNAs in organ injury: recent development.Journal of translational medicine · 2022Review
- Circ-Usp10 promotes microglial activation and induces neuronal death by targeting miRNA-152-5p/CD84.Bioengineered · 2021Article
- CircTYW1 serves as a sponge for microRNA-380 in accelerating neurological recovery following spinal cord injury via regulating FGF9.Cell cycle (Georgetown, Tex.) · 2021Article
- Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury.Frontiers in integrative neuroscience · 2021Article
- Identification of Circular RNAs Related to Vascular Endothelial Proliferation, Migration, and Angiogenesis After Spinal Cord Injury Using Microarray Analysis in Female Mice.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The central nervous system (CNS) post-traumatic injury can cause severe nerve damage with devastating consequences. However, its pathophysiological mechanisms remain vague. There is still an urgent need for more effective treatments. Circular RNAs (circRNAs) are non-coding RNAs that can form covalently closed RNA circles. Through second-generation sequencing technology, microarray analysis, bioinformatics, and other technologies, recent studies have shown that a number of circRNAs are differentially expressed after traumatic brain injury (TBI) or spinal cord injury (SCI). These circRNAs play important roles in the proliferation, inflammation, and apoptosis in CNS post-traumatic injury. In this review, we summarize the expression and functions of circRNAs in CNS in recent studies, as well as the circRNA-miRNA-mRNA interaction networks. The potential clinical value of circRNAs as a therapeutic target is also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.