Evidence map›Paper›PMID 33841421›Full record

ArticleFrontiers in immunology2021

Variants at the MHC Region Associate With Susceptibility to

Jiang Li, Yanfei Zhang, Alexandria L Jilg, Donna M Wolk, Harshit S Khara, Amy Kolinovsky, David D K Rolston, Raquel Hontecillas, Josep Bassaganya-Riera, Marc S Williams and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jiang LiDepartment of Molecular and Functional Genomics, Geisinger, Danville, PA, United States.
Yanfei ZhangGenomic Medicine Institute, Geisinger, Danville, PA, United States.
Alexandria L JilgDepartment of Internal Medicine, Geisinger, Danville, PA, United States.
Donna M WolkDiagnostic Medicine Institute, Department of Laboratory Medicine, Geisinger, Danville, PA, United States.
Harshit S KharaDepartment of Gastroenterology and Hepatology, Geisinger, Danville, PA, United States.
Amy KolinovskyPhenotype Core, Geisinger, Danville, PA, United States.
David D K RolstonDepartment of Internal Medicine, Geisinger, Danville, PA, United States.
Raquel HontecillasThe NIMML Institute, Blacksburg, VA, United States.
Josep Bassaganya-RieraThe NIMML Institute, Blacksburg, VA, United States.
Marc S WilliamsGenomic Medicine Institute, Geisinger, Danville, PA, United States.
Vida AbediDepartment of Molecular and Functional Genomics, Geisinger, Danville, PA, United States.
Ming Ta Michael LeeGenomic Medicine Institute, Geisinger, Danville, PA, United States.
Geisinger Medical Center · USGeisinger Neuroscience Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: A total of 1,160 Results: No significant genome-wide association was found in the meta-analyses of the full Conclusions: Leveraging the EHR and genetic data, genome-wide association, and fine-mapping techniques, this study identified variants and genes associated with

Indexed as

AdultAgedAged, 80 and overClostridioides difficileComplement C4aElectronic Health RecordsEnterocolitis, PseudomembranousFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHistocompatibility Antigens Class IHLA AntigensHumansMaleMiddle AgedPolymorphism, Single NucleotideComplement C4aHistocompatibility Antigens Class IHLA AntigensMHC class I-related chain ANOTCH4 protein, humanReceptor, Notch4C4aClostridioides difficileGWASMICANOTCH4

Identifiers

PMID33841421
PMCPMC8026859
OpenAlexW3149670204

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.