Evidence map›Paper›PMID 33841692›Full record

ArticleAmerican journal of translational research2021

Influence of anesthetic induction of propofol combined with esketamine on perioperative stress and inflammatory responses and postoperative cognition of elderly surgical patients.

Wencai Tu, Haibo Yuan, Shaojin Zhang, Fang Lu, Lin Yin, Chuanfeng Chen, Jianhua Li

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 64 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 7 pooled it
7.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05752409 naunknown statusnot on this map

Comparison of Esketamine-Propofol and Fentanyl-Propofol on Haemodynamics in Elderly Patients

TypeinterventionalSponsorEye & ENT Hospital of Fudan UniversityRan2021 to 2023Enrolled120ConditionsHemodynamicsArmsThe median dose of esketamine, The high dose of esketamine, Propofol
NCT06822088 phase4not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Esketamine on Oxygenation and Quality of Recovery in Patients Undergoing Thoracoscopic Surgery

TypeinterventionalSponsorJinqiao QianRan2025 to 2026Enrolled126ConditionsEsketamine, One-lung Ventilation, Oxygenation IndicesArmsEsketamine, Dexmedetomidine, Normal Saline
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 7 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wencai TuDepartment of Anesthesiology, Yichun People's Hospital Yichun 336000, Jiangxi Province, China.
Haibo YuanDepartment of Anesthesiology, Yichun People's Hospital Yichun 336000, Jiangxi Province, China.
Shaojin ZhangDepartment of Anesthesiology, Yichun People's Hospital Yichun 336000, Jiangxi Province, China.
Fang LuDepartment of Anesthesiology, Yichun People's Hospital Yichun 336000, Jiangxi Province, China.
Lin YinDepartment of Anesthesiology, Yichun People's Hospital Yichun 336000, Jiangxi Province, China.
Chuanfeng ChenDepartment of Anesthesiology, Yichun People's Hospital Yichun 336000, Jiangxi Province, China.
Jianhua LiDepartment of Anesthesiology, Yichun People's Hospital Yichun 336000, Jiangxi Province, China.
Yichun University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze the influence of anesthetic induction of propofol combined with esketamine on perioperative stress and inflammatory responses and postoperative cognition in elderly surgical patients.

methodsA total of 80 elderly surgical patients were randomly divided into a control group (n=40) and a study group (n=40). The control group received anesthetic induction with propofol combined with sufentanil, while the study group received anesthetic induction with propofol combined with esketamine. Hemodynamics, stress and inflammatory responses and changes in cognitive function, perioperative related indexes and adverse responses were compared between the two groups.

resultsAt T

conclusionThe anesthetic induction of propofol combined with esketamine, exhibits a good safety profile and reliability, it can improve hemodynamics and surgical stress and inflammatory responses, shorten anesthesia time, promote the recovery of postoperative cognitive function, and cause relatively mild adverse responses.

Indexed as

cognitive functionElderly surgical patientsesketamineinflammatory responsepropofolstress response

Identifiers

PMID33841692
PMCPMC8014402
OpenAlexW3154557415

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.