Evidence map›Paper›PMID 33842549›Full record

ArticleFrontiers in molecular biosciences2021

Modeling Microtubule Counterion Distributions and Conductivity Using the Poisson-Boltzmann Equation.

Boden B Eakins, Sahil D Patel, Aarat P Kalra, Vahid Rezania, Karthik Shankar, Jack A Tuszynski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Boden B EakinsDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada.
Sahil D PatelDepartment of Electrical and Computer Engineering, University of California, Santa Barbara, Santa Barbara, CA, United States.
Aarat P KalraDepartment of Chemistry, Princeton University, Princeton, NJ, United States.
Vahid RezaniaDepartment of Physical Sciences, MacEwan University, Edmonton, AB, Canada.
Karthik ShankarDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada.
Jack A TuszynskiDepartment of Physics, University of Alberta, Edmonton, AB, Canada.
University of Alberta · CAMacEwan University · CAPolytechnic University of Turin · ITPrinceton University · USUniversity of California, Santa Barbara · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microtubules are highly negatively charged proteins which have been shown to behave as bio-nanowires capable of conducting ionic currents. The electrical characteristics of microtubules are highly complicated and have been the subject of previous work; however, the impact of the ionic concentration of the buffer solution on microtubule electrical properties has often been overlooked. In this work we use the non-linear Poisson Boltzmann equation, modified to account for a variable permittivity and a Stern Layer, to calculate counterion concentration profiles as a function of the ionic concentration of the buffer. We find that for low-concentration buffers ([KCl] from 10 μ

Indexed as

bio-electricityCOMSOLconductivitycounter-ionscytoskeletonmicrotubulesPoisson-Boltzmann

Identifiers

PMID33842549
PMCPMC8027483
OpenAlexW3146579779

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.