Evidence map›Paper›PMID 33842883›Full record

ArticleBrain communications2021

Enhancing glucose metabolism via gluconeogenesis is therapeutic in a zebrafish model of Dravet syndrome.

Rajeswari Banerji, Christopher Huynh, Francisco Figueroa, Matthew T Dinday, Scott C Baraban, Manisha Patel

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Pharmaco-behavioral profiling identifies suppressors of autism gene-associated phenotypes in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
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  4. Article
  5. Article
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  7. Review
  8. Chronic toxicity mechanisms of 6PPD and 6PPD-Quinone in zebrafish.Environmental science and ecotechnology · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. The metabolic basis of epilepsy.Nature reviews. Neurology · 2022
    Review
  15. Review
  16. Crosstalk between neuroinflammation and oxidative stress in epilepsy.Frontiers in cell and developmental biology · 2022
    Review
  17. Use of Zebrafish Models to Boost Research in Rare Genetic Diseases.International journal of molecular sciences · 2021
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Rajeswari BanerjiSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, CA 80045, USA.
Christopher HuynhSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, CA 80045, USA.
Francisco FigueroaDepartment of Neurological Surgery, Epilepsy Research Laboratory, University of California, San Francisco, CA 94143, USA.
Matthew T DindayDepartment of Neurological Surgery, Epilepsy Research Laboratory, University of California, San Francisco, CA 94143, USA.
Scott C BarabanDepartment of Neurological Surgery, Epilepsy Research Laboratory, University of California, San Francisco, CA 94143, USA.
Manisha PatelSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, CA 80045, USA.
Neurological Surgery · USUniversity of Colorado Anschutz Medical Campus · USUniversity of California, San Francisco · USUniversity of Montana · US

Funding

SUPEROXIDE RADICALS IN SEIZURE-INDUCED NEURONAL DEATHR01NS039587 · NINDS · UNIVERSITY OF COLORADO DENVER · PI PATEL, MANISHA N · 2000 to 2019
$5.9M
ZEBRAFISH MODELS FOR DRAVET SYNDROME RESEARCH AND DISCOVERYR01NS096976 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARABAN, SCOTT C · 2016 to 2024
$3.9M
Redox Control of Seizure-Induced Neuroinflammation.R01NS086423 · NINDS · UNIVERSITY OF COLORADO DENVER · PI PATEL, MANISHA N · 2013 to 2022
$3.0M
Gluconeogenic control of Dravet SyndromeR01HD102071 · NICHD · UNIVERSITY OF COLORADO DENVER · PI BARABAN, SCOTT C, PATEL, MANISHA N · 2020 to 2024
$2.5M
NICHD NIH HHS R01 HD102071NINDS NIH HHS R01 NS039587NINDS NIH HHS R01 NS086423NINDS NIH HHS R01 NS096976
6 · The paper itself

Abstract

Energy-producing pathways are novel therapeutic targets for the treatment of neurodevelopmental disorders. Here, we focussed on correcting metabolic defects in a catastrophic paediatric epilepsy, Dravet syndrome which is caused by mutations in sodium channel NaV1.1 gene,

Indexed as

epilepsygluconeogenesismetabolismmitochondriazebrafish

Identifiers

PMID33842883
PMCPMC8023476
OpenAlexW3124536013

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.