Evidence map›Paper›PMID 33847405›Full record

ArticleJournal of leukocyte biology2022

Metabolic and functional impairment of CD8

William D Green, Abrar E Al-Shaer, Qing Shi, Kymberly M Gowdy, Nancie J MacIver, J Justin Milner, Melinda A Beck, Saame Raza Shaikh

Open access · bronzeAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

William D GreenDepartment of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
Abrar E Al-ShaerDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Qing ShiDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Kymberly M GowdyDivision of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Nancie J MacIverDepartment of Immunology, Department of Pediatrics, Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA.
J Justin MilnerDepartment of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
Melinda A BeckDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Saame Raza ShaikhDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · USDuke University · USThe Ohio State University · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JAMES E BEAR · 1985 to 2026
$201.5M
Treatment of Peanut Allergy with Intradermal Administration of ASP0892 (ARA-LAMP-vax): A Randomized, Double-Blind, Placebo-Controlled, Phase I/II StudyUM2AI130836 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WOOD, ROBERT A · 2017 to 2023
$62.1M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
NUTRITION TRAINING PROGRAMT32DK007686 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BECK, MELINDA A., MAYER-DAVIS, ELIZABETH J · 1992 to 2022
$4.3M
Dietary EPA mitigates ozone induced pulmonary inflammation through ChemR23 signalingR01ES031378 · NIEHS · OHIO STATE UNIVERSITY · PI Kymberly Mae Gowdy, SAAME R SHAIKH · 2020 to 2026
$3.7M
Suppressing inflammation and boosting humoral immunity with n-3 PUFAsR01AT008375 · NCCIH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHAIKH, SAAME R · 2015 to 2019
$1.9M
Mechanisms of T cell inflammation in obesity-induced type 2 diabetesR01DK106090 · NIDDK · DUKE UNIVERSITY · PI MACIVER, NANCIE · 2015 to 2019
$1.8M
NCCIH NIH HHS R01 AT008375NCI NIH HHS P30 CA016086NIAID NIH HHS UM2 AI130836NIDDK NIH HHS P30 DK056350NIDDK NIH HHS T32 DK007686NIEHS NIH HHS R01 ES031378
6 · The paper itself

Abstract

Obesity is an independent risk factor for morbidity and mortality in response to influenza infection. However, the underlying mechanisms by which obesity impairs immunity are unclear. Herein, we investigated the effects of diet-induced obesity on pulmonary CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesHumansImmunityInfluenza A virusInfluenza, HumanLungMaleMiceMice, Inbred C57BLMice, ObeseObesityOrthomyxoviridae InfectionsEffectorImmunityPulmonary

Identifiers

PMID33847405
PMCPMC8787296
OpenAlexW3155365544

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.