Evidence map›Paper›PMID 33848005›Full record

ArticleAdvances in experimental medicine and biology2021

Mitochondria: The Retina's Achilles' Heel in AMD.

Deborah A Ferrington, M Cristina Kenney, Shari R Atilano, James B Hurley, Emily E Brown, John D Ash

Abstract read
PubMed Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Deborah A FerringtonDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA. ferri013@umn.edu.
M Cristina KenneyGavin Herbert Eye Institute, University of California, Irvine, Irvine, CA, USA.
Shari R AtilanoGavin Herbert Eye Institute, University of California, Irvine, Irvine, CA, USA.
James B HurleyDepartments of Biochemistry and Ophthalmology, University of Washington, Seattle, WA, USA.
Emily E BrownDepartment of Ophthalmology, University of Florida, Gainesville, FL, USA.
John D AshDepartment of Ophthalmology, University of Florida, Gainesville, FL, USA.
University of California, Irvine · USUniversity of Florida · USUniversity of Minnesota · USUniversity of Washington · US

Funding

Regulators of retinal metabolism in healthy and degenerating retinasR01EY031720 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ASH, JOHN D, DU, JIANHAI · 2020 to 2024
$2.4M
NEI NIH HHS R01 EY031720
6 · The paper itself

Abstract

Strong experimental evidence from studies in human donor retinas and animal models supports the idea that the retinal pathology associated with age-related macular degeneration (AMD) involves mitochondrial dysfunction and consequent altered retinal metabolism. This chapter provides a brief overview of mitochondrial structure and function, summarizes evidence for mitochondrial defects in AMD, and highlights the potential ramifications of these defects on retinal health and function. Discussion of mitochondrial haplogroups and their association with AMD brings to light how mitochondrial genetics can influence disease outcome. As one of the most metabolically active tissues in the human body, there is strong evidence that disruption in key metabolic pathways contributes to AMD pathology. The section on retinal metabolism reviews cell-specific metabolic differences and how the metabolic interdependence of each retinal cell type creates a unique ecosystem that is disrupted in the diseased retina. The final discussion includes strategies for therapeutic interventions that target key mitochondrial pathways as a treatment for AMD.

Indexed as

DNA, MitochondrialMacular DegenerationAnimalsEcosystemHumansMitochondriaRetinaRetinal Pigment EpitheliumDNA, MitochondrialAge-related macular degenerationEcosystem modelMetabolismMitochondriamtDNAProteomics

Identifiers

PMID33848005
OpenAlexW3156807586

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.