Evidence map›Paper›PMID 33849827›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021

[Exenatide promotes cholesterol efflux in pancreatic tissue of obese diabetic rats].

L Zhao, X Zhang, J Feng, Z Xiao, Y Liu, H Long, X Chen, W Tang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

L ZhaoDepartment of Gastrointestinal Surgery, First Affiliated Hospital, University of South China, Hengyang 421001, China.
X ZhangDepartment of Gastrointestinal Surgery, First Affiliated Hospital, University of South China, Hengyang 421001, China.
J FengResearch Lab of Translational Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China.
Z XiaoDepartment of Gastrointestinal Surgery, First Affiliated Hospital, University of South China, Hengyang 421001, China.
Y LiuDepartment of Gastrointestinal Surgery, First Affiliated Hospital, University of South China, Hengyang 421001, China.
H LongDepartment of Gastrointestinal Surgery, First Affiliated Hospital, University of South China, Hengyang 421001, China.
X ChenDepartment of Gastrointestinal Surgery, First Affiliated Hospital, University of South China, Hengyang 421001, China.
W TangDepartment of Hepatobiliary Surgery, First Affiliated Hospital, University of South China, Hengyang 421001, China.
University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the effect of exenatide on the expression of ABCA1 and cholesterol metabolism in the pancreas of obese diabetic rats.

objectiveTwenty-four normal male SD rats and 18 obese diabetic rats (induced by high-fat feeding and STZ injection) were both divided equally into 2 groups for injections of saline or exenatide. After treatment for a week, the expression of ABCA1, cholesterol metabolism, and islet function of the rats were examined using real-time PCR, Western blotting, oil red O staining, cholesterol content determination, and HE staining.

objectiveThe expressions of ABCA1 at both mRNA and protein levels in pancreatic tissue were significantly lower in obese diabetic rats than in normal SD rats. The obese diabetic rats showed obvious lipid deposition and increased cholesterol content in the pancreatic tissue with significantly reduced islet volume and structural changes (

objectiveObese diabetic rats have lowered ABCA1 expression, cholesterol efflux block, and cholesterol accumulation in the pancreatic tissue. Exenatide can up-regulate ABCA1 expression and promote cholesterol efflux to reduce cholesterol content in the pancreatic tissue and improve islet function in obese diabetic rats.

Indexed as

Diabetes Mellitus, ExperimentalAnimalsATP Binding Cassette Transporter 1CholesterolExenatideMaleObesityPancreasRatsRats, Sprague-DawleyATP Binding Cassette Transporter 1CholesterolExenatideABCA1cholesterol effluxexenatidepancreas

Identifiers

PMID33849827
PMCPMC8075781
OpenAlexW3152951502

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.