Evidence map›Paper›PMID 33850212›Full record

ArticleScientific reports2021

Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice.

Henrik H Hansen, Rikke V Grønlund, Tamara Baader-Pagler, Peter Haebel, Harald Tammen, Leif Kongskov Larsen, Jacob Jelsing, Niels Vrang, Thomas Klein

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Neuropeptide Y Peptide Family and Cancer: Antitumor Therapeutic Strategies.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Review
  5. Targeting the Enteroendocrine System for Treatment of Obesity.Handbook of experimental pharmacology · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Henrik H HansenGubra, Hørsholm Kongevej 11B, 2970, Hørsholm, Denmark. hbh@gubra.dk.
Rikke V GrønlundGubra, Hørsholm Kongevej 11B, 2970, Hørsholm, Denmark.
Tamara Baader-PaglerDepartment of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co., Biberach, Germany.
Peter HaebelDepartment of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co., Biberach, Germany.
Harald TammenPXBioVisioN, Hannover, Germany.
Leif Kongskov LarsenGubra, Hørsholm Kongevej 11B, 2970, Hørsholm, Denmark.
Jacob JelsingGubra, Hørsholm Kongevej 11B, 2970, Hørsholm, Denmark.
Niels VrangGubra, Hørsholm Kongevej 11B, 2970, Hørsholm, Denmark.
Thomas KleinDepartment of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co., Biberach, Germany.
Gubra (Denmark) · DKBoehringer Ingelheim (Germany) · DEPXBioVisioN (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dipeptidyl peptidase IV (DPP-IV) inhibitors improve glycemic control by prolonging the action of glucagon-like peptide-1 (GLP-1). In contrast to GLP-1 analogues, DPP-IV inhibitors are weight-neutral. DPP-IV cleavage of PYY and NPY gives rise to PYY

Indexed as

Dipeptidyl-Peptidase IV InhibitorsLinagliptinMice, ObeseObesityPeptide YYReceptors, Neuropeptide YAnimalsBlood GlucoseDiet, High-FatEatingMaleMiceMice, Inbred C57BLPeptide FragmentsWeight LossBlood GlucoseDipeptidyl-Peptidase IV InhibitorsLinagliptinneuropeptide Y2 receptorPeptide FragmentsPeptide YYpeptide YY (3-36)Receptors, Neuropeptide Y

Identifiers

PMID33850212
PMCPMC8044192
OpenAlexW3155964814

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.