Evidence map›Paper›PMID 33850573›Full record

ReviewJournal of arrhythmia2021

Atrial fibrillation and autonomic nervous system: A translational approach to guide therapeutic goals.

Marco Rebecchi, Germana Panattoni, Bressi Edoardo, Ermenegildo de Ruvo, Luigi Sciarra, Alessandro Politano, Marianna Sgueglia, Chiara Ricagni, Sara Verbena, Cinzia Crescenzi and 8 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of arrhythmia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Marco RebecchiDepartment of Cardiology Policlinico Casilino Rome Italy.ORCID https://orcid.org/0000-0001-9144-0455
Germana PanattoniDepartment of Cardiology Policlinico Casilino Rome Italy.
Bressi EdoardoDepartment of Cardiology Policlinico Casilino Rome Italy.
Ermenegildo de RuvoDepartment of Cardiology Policlinico Casilino Rome Italy.
Luigi SciarraDepartment of Cardiology Policlinico Casilino Rome Italy.
Alessandro PolitanoDepartment of Cardiology Policlinico Casilino Rome Italy.
Marianna SguegliaDepartment of Cardiology Policlinico Casilino Rome Italy.
Chiara RicagniDepartment of Cardiology Policlinico Casilino Rome Italy.
Sara VerbenaDepartment of Cardiology Policlinico Casilino Rome Italy.
Cinzia CrescenziDepartment of Cardiology Policlinico Casilino Rome Italy.
Catia SangiorgiDepartment of Cardiology Policlinico Casilino Rome Italy.
Alessio BorrelliDepartment of Cardiology Policlinico Casilino Rome Italy.
Lucia De LucaDepartment of Cardiology Policlinico Casilino Rome Italy.
Antonio ScaràDepartment of Cardiology Policlinico Casilino Rome Italy.
Domenico GriecoDepartment of Cardiology Policlinico Casilino Rome Italy.
Ilaria JacomelliDepartment of Cardiology Policlinico Casilino Rome Italy.
Annamaria MartinoDepartment of Cardiology Policlinico Casilino Rome Italy.
Leonardo CalòDepartment of Cardiology Policlinico Casilino Rome Italy.
Policlinico Casilino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The autonomic nervous system (ANS) is known to play an important role in the genesis and maintenance of atrial fibrillation (AF). Biomolecular and genetic mechanisms, anatomical knowledges with recent diagnostic techniques acquisitions, both invasive and non-invasive, have enabled greater therapeutic goals in patients affected by AF related to ANS imbalance. Catheter ablation of ganglionated plexi (GP) in the left and right atrium has been proposed in varied clinical conditions. Moreover interesting results arise from renal sympathetic denervation and vagal nerve stimulation. Despite all this, in the scenario of ANS modulation translational strategies we necessary must consider the treatment or correction of dynamic factors such as obesity, obstructive sleep apnea, lifestyle, food, and stress. Finally, new antiarrhythmic drugs, gene therapy and "ablatogenomic" could be represent exciting future therapeutic perspectives.

Indexed as

atrial fibrillationautonomic nervous system denervationganglionated plexi

Identifiers

PMID33850573
PMCPMC8022002
OpenAlexW3127449961

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.